AI Article Synopsis
- Cancer development is influenced by signaling pathways that control cellular processes like growth and survival, with the insulin signaling pathway playing a key role.
- Recent studies indicate that tumor cells often have an overactive insulin pathway, which helps them grow, while also inhibiting healthy tissue growth by disrupting their insulin signaling.
- Understanding how the insulin network affects cancer cell behavior could lead to new cancer treatment options.
Article Abstract
Cancer development is related to a variety of signaling pathways which mediate various cellular processes including growth, survival, division and competition of cells, as well as cell-cell interaction. The insulin signaling pathway interacts with different pathways and plays a core role in the regulations of all these processes. In this study, we reviewed recent studies on the relationship between the insulin signaling pathway and tumors using the model. We found that on one hand, the insulin pathway is normally hyperactive in tumor cells, which promotes tumor growth, and on the other hand, tumor cells can suppress the growth of healthy tissues via inhibition of their insulin pathway. Moreover, systematic disruption in glucose homeostasis also facilitates cancer development by different mechanisms. The studies on how the insulin network regulates the behaviors of cancer cells may help to discover new therapeutic treatments for cancer.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304707 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2022.e09957 | DOI Listing |
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