Our editor discusses brain resilience and how it can be harnessed to prevent diseases that cause dementia.
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| http://dx.doi.org/10.1093/braincomms/fcac160 | DOI Listing |
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Tile: Construction of a specific nanoprobe for scavenging ROS in hypobaric hypoxia induced brain injury of mice.
Heliyon
October 2024
Innovative Institute of Chinese Medicine and Pharmacy/Academy for Interdiscipline, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Article Synopsis
- The study addresses the challenge of preventing and treating hypobaric hypoxia brain injury (HHBI) by utilizing RuCO phthalocyanine nanoparticles combined with bovine serum albumin (BSA) for targeted therapy.
- RuPc-BSA nanoparticles serve as a vehicle to deliver carbon monoxide (CO) to injured areas in the brain, which helps reduce harmful reactive oxygen species (ROS) by binding to mitochondrial heme groups.
- Experimental results show that RuPc-BSA not only lowers ROS levels and improves neuronal function but also enhances the Nrf2 signaling pathway, indicating its potential effectiveness in mitigating HHBI.
[Understanding Franz Kafka from the Neuroscientific Perspective].
Brain Nerve
December 2024
Department of Physiology, Tohoku University School of Medicine.
Franz Kafka (1883-1924) was a novelist from what is now the Czech Republic, and is one of the figures who symbolize modern world literature. Although his works are more than 100 years old, Kafka displays amazing foresight regarding modern society; his writing portrays many original and unusual settings with extremely realistic expressions of individuals who find themselves in solitude caught in a huge inhuman system that typifies the current society. In this report, I discuss the association between such originality and Kafka's solitary interiority from a neuroscientific perspective.
View Article and Find Full Text PDF"In a State of Flow": A Qualitative Examination of Autistic Adults' Phenomenological Experiences of Task Immersion.
Autism Adulthood
September 2024
Macquarie School of Education, Macquarie University, Sydney, Australia.
Background: There is considerable conceptual overlap between Autistic hyperfocus and flow, yet these phenomena have seldom been associated in the literature. Moreover, no studies have provided an in-depth empirical investigation of Autistic people's flow-like or hyperfocus experiences. In this study, we sought to address this gap by investigating Autistic people's phenomenological experiences of task immersion, and how their experiences relate to existing conceptualizations of flow, hyperfocus, and monotropism.
View Article and Find Full Text PDFOptogenetics Neuromodulation of the Nose.
Behav Neurol
August 2024
E.N.T. Department Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Recently developed optogenetic technology, which allows high-fidelity control of neuronal activity, has been applied to investigate the neural circuits underlying sensory processing and behavior. The nasal cavity is innervated by the olfactory nerve and trigeminal nerve, which are closely related to common symptoms of rhinitis, such as impairment of smell, itching, and sneezing. The olfactory system has an amazing ability to distinguish thousands of odorant molecules at trace levels.
View Article and Find Full Text PDFThe vertebrate retina: a window into the evolution of computation in the brain.
Curr Opin Behav Sci
June 2024
Center for Sensory Neuroscience and Computation, School of Life Sciences, University of Sussex, Brighton BN19QG, UK.
Animal brains are probably the most complex computational machines on our planet, and like everything in biology, they are the product of evolution. Advances in developmental and palaeobiology have been expanding our general understanding of how nervous systems can change at a molecular and structural level. However, how these changes translate into altered function - that is, into 'computation' - remains comparatively sparsely explored.
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