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Extensively Drug-Resistant in Critically Ill Patients: A Case Series and Literature Review. | LitMetric
The bacterial genus , like other members of the family, consists of aerobic, non-motile, Gram-negative bacilli. spp. is considered predominantly opportunistic pathogens as, historically, most documented infections have been in immunocompromised individuals. Along with advancements in molecular assay testing, there are growing reports of clinically relevant spp. infections in immunocompetent individuals. These organisms display broad antimicrobial resistance, and while research into their mechanisms of resistance is progressing, genetic testing has revealed metallo--lactamases present in their genome. The sporadic identification of spp. and ongoing clarification of resistance patterns make empiric treatment difficult. This report documents two cases of extensively drug-resistant isolated from critically ill but otherwise immunocompetent patients followed by a review of available literature on spp. antibiotic sensitivities. Our findings indicate that minocycline and moxifloxacin have the highest documented activity against spp.
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