Two new pyranone derivatives phomapyrone A (2) and phomapyrone B (3), one new coumarin 11 13-(+)-phomacumarin A (1), three known pyranones (4-6), together with three known amide alkaloids fuscoatramides A-C (7-9), as well as 9 11-(+)-ascosalitoxin (10) were isolated from the endophytic fungus sp. YN02-P-3, which was isolated from the healthy leaf tissue of a Paulownia tree in Yunnan Province, China. Their structures were elucidated using extensive NMR spectroscopic and HRESIMS data and by comparing the information with literature data. In addition, all compounds were tested for their cytotoxicity activity against human tumor cell lines, and the results showed that new compounds 1-3 showed moderate inhibitory activity against the HL-60 cell line with IC values of 31.02, 34.62, and 27.90 M, respectively.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300907 | PMC |
| http://dx.doi.org/10.3389/fchem.2022.950726 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Divergent Synthesis of Axially Chiral 2-Pyranones and Fused 2-Pyridones via -Heterocyclic Carbene-Catalyzed Atroposelective [3 + 3] Annulation.
J Org Chem
January 2025
School of Science, China Pharmaceutical University, Nanjing 210009, P. R. China.
An -heterocyclic carbene-catalyzed atroposelective [3 + 3] annulation of alkynyl acylazoliums with benzothiazole derivatives has been developed for the divergent synthesis of axially chiral triaryl 2-pyranones and fused 2-pyridones. The regioselectivity of this protocol depends on the structure of benzothiazoles with three different nucleophilic centers. The obtained axially chiral frameworks represent a new class of arylheterocycle atropisomers, which may be potentially useful in medicinal chemistry.
View Article and Find Full Text PDFSynthesis of Stereochemical Library of a Potent Antimalarial Monocerin Derivative and Its Stereochemical Revision.
Org Lett
August 2024
Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad 500007, India.
Article Synopsis
- - The study details the total synthesis of a potent antimalarial compound based on a benzo-pyranone framework, derived from the natural product (+)-monocerin found in marine fungi.
- - Key methods used in the synthesis include chiral hypervalent iodine(III)-catalyzed oxylactonization and late-stage methylation, which are crucial for creating the compound.
- - The researchers aimed to produce a library of all eight stereoisomers to better understand the relationship between stereochemistry and the compound's activity against malaria (S-SARs).
Photophysics of Molecular Probes for Amyloid-β Detection: Computational Insights into the Roles of Probe Linker and Functional Groups.
J Phys Chem A
August 2024
Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.
In this computational study, density functional theory (DFT) and time-dependent DFT methods (TD-DFT) were employed to study the optical properties of six families of molecules with donor (D), bridge (B), and acceptor (A) fragments that have potential for use as fluorescent molecular probes for the early detection of Alzheimer's disease. After validating our computational method against experimental data, using X-ray and absorption data, the equilibrium geometries and wave functions of the ground and first singlet excited states were systematically studied. Our simulations demonstrate that the S states of these rod-like D-B-A fluorescent probes are twisted intramolecular charge transfer states with a predominant highest occupied molecular orbital-least unoccupied molecular orbital (HOMO-LUMO) character, the former localized primarily at the donor, whereas the latter at the acceptor site.
View Article and Find Full Text PDFAn Overview of the Synthesis of 3,4-Fused Pyrrolocoumarins of Biological Interest.
Molecules
June 2024
Laboratory of Organic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
3,4-Fused pyrrolocoumarins, synthetically prepared or naturally occurring, possess interesting biological properties. In this review, the synthetic strategies for the synthesis of the title compounds are presented along with their biological activities. Two routes are followed for that synthesis.
View Article and Find Full Text PDFSynthesis of 1,2,3-triazoles containing an allomaltol moiety from substituted pyrano[2,3-]isoxazolones via base-promoted Boulton-Katritzky rearrangement.
Beilstein J Org Chem
June 2024
N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Pr., 47, Moscow, 119991, Russian Federation.
For the first time, the interaction of aroyl containing pyrano[2,3-]isoxazolone derivatives with various hydrazines was studied. It was shown that the considered process includes formation of corresponding hydrazones followed by Boulton-Katritzky rearrangement. As a result, the general method for the synthesis of substituted 1,2,3-triazoles bearing an allomaltol fragment was elaborated.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!