Obesity is a growing medical and social problem worldwide. The control of energy homeostasis in the brain is achieved by various regions including the arcuate hypothalamic nucleus (ARH). The latter comprises a number of neuronal populations including the first order metabolic neurons, appetite-stimulating agouti-related peptide (AgRP) neurons and appetite-suppressing proopiomelanocortin (POMC) neurons. Using an reductionist approach and POMC-dependent CRISPR-Cas9, we demonstrate that miR-15a-5p protects from obesity. Moreover, we have identified , a gene previously linked to energy metabolism imbalance, as a direct target of miR-15a-5p. This work warrants further investigations of non-coding RNA-mediated regulation of energy homeostasis and might contribute to the development of novel therapeutic approaches to treat metabolic diseases.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9302447 | PMC |
| http://dx.doi.org/10.3389/fendo.2022.867929 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Invited Review: The impact of the dairy food matrix on digestion and absorption.
J Dairy Sci
January 2025
Riddet Institute, Private Bag 11 222, Palmerston North 4442, New Zealand. Electronic address:
The nutritional value of any food product has historically been measured by the calorific value of individual components, harking back to the days of the development of the bomb calorimeter. A fuller understanding of nutrition later took into account the need for specific components, such as proteins, carbohydrates, vitamins and minerals, that ere known to be required for good human health and growth. In milk and milk products, these include casein and whey proteins, lactose, milk fat triacylglycerides, minor lipid components (both charged and neutral), calcium, and micronutrients.
View Article and Find Full Text PDFPCA-based spatial domain identification with state-of-the-art performance.
Bioinformatics
January 2025
Institute of Medical Systems Biology, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, 20251, Hamburg, Germany.
Motivation: The identification of biologically meaningful domains is a central step in the analysis of spatial transcriptomic data.
Results: Following Occam's razor, we show that a simple PCA-based algorithm for unsupervised spatial domain identification rivals the performance of ten competing state-of-the-art methods across six single-cell spatial transcriptomic datasets. Our reductionist approach, NichePCA, provides researchers with intuitive domain interpretation and excels in execution speed, robustness, and scalability.
Obstructed Labor, Evolution, and Health Disparities.
Biology (Basel)
December 2024
Department of Anatomy, Howard University, Washington, DC 20059, USA.
The female pelvis is often evolutionarily described as a compromise to accommodate the birthing process and bipedalism. This compromise puts a mother and baby at risk of fetopelvic disproportion, the mismatch between the size of the fetus and that of the mother's pelvis, impacting the ease with which the vaginal birthing process occurs. Obstructed labor, commonly caused by fetopelvic disproportion, is a leading cause of maternal mortality and morbidity and has serious medical sequelae for the fetus.
View Article and Find Full Text PDFCan a plant biologist fix a thermostat?
New Phytol
January 2025
Plant Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, 92037-100210, USA.
The shift to reductionist biology at the dawn of the genome era yielded a 'parts list' of plant genes and a nascent understanding of complex biological processes. Today, with the genomics era in full swing, advances in high-definition genomics enabled precise temporal and spatial analyses of biological systems down to the single-cell level. These insights, coupled with artificial intelligence-driven in silico design, are propelling the development of the first synthetic plants.
View Article and Find Full Text PDFFor people with mental and somatic illnesses, the interpretive process of attending to a multitude of bodily sensations and recognising them as potential symptoms represents daily and 'chronic homework'. Based on 16 months of ethnographic fieldwork in Denmark, this study explores diagnostic work and healthcare seeking among people with severe mental and somatic illnesses. As multiple studies have shown, the transformation process for a perceived sensation to become a symptom is a socially constructed interpretative process highly dependent on social legitimisation and shaped by prior cultural knowledge.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!