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It has been reported that there were several "mutant isolated in the field " of African swine fever virus (ASFV) since ASFV was reported, which may be the result of the continuous adaptation and evolution of ASFV. The emergence of ASFV field mutants may lead to chronic or asymptomatic "atypical clinical symptoms" in pigs and hinder the development of porcine industry. Here we analyzed the published ASFV "field attenuated strain" gene sequences and reviewed the genetic differences between field attenuated and virulent ASFV strains, hoping for providing a reference for the scientific prevention and control of ASF and the development of new vaccines. In this study we found the deletion of EP153R and EP402R occurred in 4 field attenuated strains, and all the differential genes of field attenuated strains mainly range in regions with low GC content. The evolution of MGF110 family genes was identified by analysis of two field attenuated ASFV strains from Portugal. We also found that some tandem repeat sequence plays an important role in the evolution of strains of NH/P68 and OURT 88/3 but not in strains Estonia 2014, HuB20 and Pig/Heilongjiang/HRB1/2020.
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http://dx.doi.org/10.1016/j.virusres.2022.198874 | DOI Listing |
Naunyn Schmiedebergs Arch Pharmacol
December 2024
Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India.
Idiopathic pulmonary fibrosis (IPF) is a severe and progressive lung disorder with an average survival rate of 3 to 5 years. IPF presents a significant challenge in clinical management, necessitating novel therapeutic approaches. Nanostructured lipid carriers (NLCs) have proven to be promising vehicles for targeted drug delivery to the lung tissues.
View Article and Find Full Text PDFBehav Pharmacol
December 2024
Department of Pharmacology, Center of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom, South Africa.
Traumatic stress exposure increases noradrenaline (NA) release, which contributes to anxiety and impaired risk-appraisal. Guanfacine, a selective alpha-2A adrenergic receptor agonist, has been used to treat stress-related disorders characterised by impaired prefrontal cortex function. By acting on both presynaptic inhibitory autoreceptors and postsynaptic heteroreceptors, guanfacine attenuates stress reactivity and enhances cognition.
View Article and Find Full Text PDFChemosphere
December 2024
Département des sciences de la Terre et de l'atmosphère, Université du Québec à Montréal, Montréal, QC H2X 1Y4, Canada; Geotop Research Centre, Montréal, QC H2X 3Y7, Canada. Electronic address:
Many processes can contribute to the attenuation of the frequently detected and toxic herbicides atrazine and metolachlor in surface water, including photodegradation. Multi-element compound-specific isotope analysis has the potential to decipher between these different degradation pathways as Cl is a promising tool for both pathway identification and a sensitive indicator of degradation for both atrazine and metolachlor. In this study, photodegradation experiments of atrazine and metolachlor were conducted under simulated sunlight in buffered solutions (direct photodegradation) and with nitrate (indirect photodegradation by OH radicals) to determine kinetics, transformation products and isotope fractionation for C, N and for the first time Cl.
View Article and Find Full Text PDFCell Mol Biol (Noisy-le-grand)
November 2024
Department of Plant Sciences and Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.
The present study aimed to investigate the impact of progressive drought stress (100%, 75%, 50%, and 25% of field capacity) on photosynthetic light reactions of tomato plants. The imposed drought caused a gradual reduction in leaf RWC leading to a decline in pigment concentration and growth indices. Significant alteration in the OJIP fluorescence transient curves and the formation of specific fluorescence bands (L, K, J, H, and G) gradually increased as drought severity increased.
View Article and Find Full Text PDFEnviron Health
December 2024
Department of Pediatric Cardiology, School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, NO1665 Kongjiang Road, Shanghai, 200092, China.
Background: Congenital heart disease (CHD) is a common birth defect. Our previous studies suggest that indoor air pollution, especially total volatile organic compounds (TVOCs), may increase fetal CHD risk, whereas vitamin and folic acid (FA) supplements in early pregnancy might offer protection against CHD. However, limited research has explored whether FA or multivitamin supplementation can mitigate the effects of TVOCs exposure on CHD.
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