AI Article Synopsis
- The objective of the study is to examine the clinical and laboratory features of inborn errors of immunity (IEI) linked to elevated immunoglobulin E (IgE) levels.
- The research involves a thorough review of primary peer-reviewed literature, including various types of studies on IEI.
- The findings highlight that IEI should be investigated in patients with high IgE levels, particularly those experiencing recurrent infections or other related health issues.
Article Abstract
Objective: To review the characteristic clinical and laboratory features of inborn errors of immunity (IEI) that are associated with elevated immunoglobulin (Ig)E levels.
Data Sources: Primary peer-reviewed literature.
Study Selections: Original research articles reviewed include interventional studies, retrospective studies, case-control studies, cohort studies, and review articles related to the subject matter.
Results: An extensive literature review was completed to allow for comprehensive evaluation of several monogenic IEI. This review includes a description of the classic clinical features, common infections, characteristic laboratory findings, specific diagnostic methods (when applicable), and genetic basis of disease of each syndrome. A comprehensive flow diagram was created to assist them in the diagnosis and evaluation of patients with elevated IgE levels who may require evaluation for an IEI.
Conclusion: IEI should be considered in patients with elevated IgE levels, especially if they have recurrent infections, eczematous dermatitis, malignancy, lymphoproliferation, autoimmunity, or connective tissue abnormalities.
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| http://dx.doi.org/10.1016/j.anai.2022.07.013 | DOI Listing |
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