AI Article Synopsis
- An 82-year-old male developed subacute sensorimotor neuropathy after an Epstein-Barr virus (EBV) infection, initially experiencing diplopia and limb weakness that affected his gait.
- Biopsy of a cervical lymph node revealed a high presence of EBV-positive cells, while nerve conduction studies indicated both axonal damage and demyelination.
- The patient showed improvement with corticosteroid treatment, regaining the ability to walk independently after four months, with the neuropathy thought to result from vasculitic and immune-mediated processes linked to EBV reactivation.
Article Abstract
We report the case of an 82-year-old male with subacute sensorimotor neuropathy associated with Epstein-Barr virus (EBV) infection, who presented with diplopia followed by gait disturbance due to limb weakness. Pathological findings of a biopsied cervical lymph node showed a high frequency of EBV-positive cells. EBV-DNA was detected in blood. A nerve conduction study suggested a mixture of axonal damage and demyelination. Brain MRI showed multiple microbleeds in cerebellar cortices, but cerebrospinal fluid EBV-PCR was negative, suggesting bleeding due to EBV-related vasculitis. Corticosteroid therapy improved the neurological symptoms and the patient was able to walk independently four months later. The main pathogenesis of the neuropathy in this case is likely to be a mixture of vasculitic neuropathy and immune-mediated demyelinating neuropathy, which are considered to be due to EBV reactivation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.5692/clinicalneurol.cn-001726 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!