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Biological contaminants analysis in microalgae culture by UV-vis spectroscopy and machine learning.
Spectrochim Acta A Mol Biomol Spectrosc
January 2025
VTT Technical Research Centre of Finland Ltd, Tietotie 2, P.O. Box 1000, 02044 Espoo, Finland.
This study elucidates the utility and efficacy of UV-visible spectroscopy for the detection and characterization of biological contaminants within microalgae cultures, augmented by machine learning algorithms. Biological contamination, exemplified by flagellates and rotifers, poses a significant concern due to its potential to rapidly devastate entire cultures, thus jeopardizing commercial viability. Conventional analytical methods for monitoring contamination, such as microscopy and cytometry, are often labor-intensive, reliant on specialized expertise for microorganism identification, and may lack specificity in discerning the nature of contamination, impeding timely intervention.
View Article and Find Full Text PDFAdvanced whole transcriptome sequencing and artificial intelligence/machine learning (AI/ML) in imiquimod-induced psoriasis-like inflammation of human keratinocytes.
Biomedicine (Taipei)
December 2024
Million-Person Precision Medicine Initiative, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
Introduction: Although the HaCaT keratinocyte model has been used in previous research to study the effects of antipsoriatic agents, there is still a lack of comprehensive understanding of the mechanism of imiquimod (IMQ)-induced proliferation and signal transduction in psoriasis-like keratinocytes.
Objectives: This study aimed to investigate the molecular mechanisms and pathways associated with psoriasis-like inflammation caused by IMQ in human keratinocytes.
Materials And Methods: HaCaT cells were exposed to different concentrations of IMQ to induce inflammation similar to that observed in psoriasis.
Misreading Medicine: Statutory Prohibitions of Abortion for Disability.
J Med Humanit
January 2025
S.J. Quinney College of Law, University of Utah, Salt Lake City, UT, USA.
Abortion prohibitions in some states include carve-outs based on the medical condition of either the mother or the fetus. These carve-outs, however, may be couched in limiting language structured by legislators rather than in language understandable in the context of medical care. In circumstances where legislative bodies fail to adequately incorporate medical professionals in the drafting of medical laws, the resulting vagueness or ambiguity may lead to a lack of utility or viability.
View Article and Find Full Text PDFimpairs T cell priming by inducing dendritic cell death.
Infect Immun
January 2025
1Department of Microbiology, Harvard Medical School, Boston, Massachusetts, USA.
The lack of effective adaptive immunity against leads to chronic or repeated infection and serious disease sequelae. Dendritic cells (DCs) are professional antigen-presenting cells that are crucial for the activation of T cells during infection. cDC1s and cDC2s are the two main DC subsets responsible for T cell priming, but little is known about how affects their ability to prime T cells.
View Article and Find Full Text PDFMesoporous Polydopamine Nano-Bowls Demonstrate a High Entrapment Efficiency and pH-Responsive Release of Paclitaxel for Suppressing A549 Lung Cancer Cell Proliferation In Vitro.
Pharmaceutics
December 2024
Wits Advanced Drug Delivery Platform, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, South Africa.
The effectiveness of paclitaxel (PTX) in treating non-small-cell lung carcinoma (NSCLC) is restricted by its poor pharmacokinetic profile and side effects. This limitation stems from the lack of a suitable delivery vector to efficiently target cancer cells. Therefore, there is a critical need to develop an efficient carrier for the optimised delivery of PTX in NSCLC therapy.
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