AI Article Synopsis
- * Researchers compared 19 MA users to 21 people who don’t use the drug, using a special brain scan called resting-state fMRI.
- * They found that MA users had changes in certain brain networks that may lead to problems with decision making and controlling drug use, especially related to how long they have been using MA or how long they have stopped.
Article Abstract
This study set out to assess restingstate functional connectivity (rs-FN) and graph theorybased local efficiency within the left and right hemispheres of methamphetamine (MA) users. Functional brain networks of 19 MA users and 21 control participants were analyzed using restingstate fMRI. Graph edges in functional networks of the brain were defined and recurrence plot was used. We found that MA abuse may be accompanied by alterations of rs-FN within the defaultmode network (DMN), executive control network (ECN), and the salience network (SN) in both hemispheres of the brain. Moreover, we observed that such effects of MA may be correlated with duration of MA abuse and MA abstinence in many components of the DMN and SN. The results would seem to suggest that MAinduced alterations of local efficiency may, in part, account for maladaptive decision making, deficits in executive function and control over drug seeking/taking, and relapse.
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| http://dx.doi.org/10.1016/j.bbr.2022.114022 | DOI Listing |
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