AI Article Synopsis

  • - The spike antibody is commonly used in COVID-19 vaccines, while SARS-CoV-2 nucleocapsid antibodies help determine past infections in blood tests.
  • - There's limited understanding of how these nucleocapsid antibodies change over time and their decline (seroreversion).
  • - The research indicates significant drops in nucleocapsid antibodies, suggesting that studies on past infections need to consider this decline for accuracy.

Article Abstract

Given widespread use of spike antibody in generating coronavirus disease vaccines, SARS-CoV-2 nucleocapsid antibodies are increasingly used to indicate previous infection in serologic surveys. However, longitudinal kinetics and seroreversion are poorly defined. We found substantial seroreversion of nucleocapsid total immunoglobulin, underscoring the need to account for seroreversion in seroepidemiologic studies.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9423917PMC
http://dx.doi.org/10.3201/eid2809.220729DOI Listing

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