AI Article Synopsis
- Researchers are focusing on creating antiviral treatments that target the host’s immune response rather than just the virus itself, which may help against new viruses.
- In a recent study published in Cell Chemical Biology, Maarifi and team used a specialized assay to identify small molecules that could fight viral infections.
- They discovered that Gilteritinib boosts interferon production and helps reduce virus replication, suggesting its potential as an antiviral agent.
Article Abstract
Developing broad-spectrum, host-directed antiviral therapeutics can be adapted to combat emerging viruses. In this issue of Cell Chemical Biology, Maarifi and colleagues implement a Nano luciferase reporter-based protein complementation assay to screen for small molecules and identify Gilteritinib, which enhances interferon induction and antagonizes virus replication.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9548442 | PMC |
| http://dx.doi.org/10.1016/j.chembiol.2022.06.009 | DOI Listing |
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