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Complosome Regulates Hematopoiesis at the Mitochondria Level.
Stem Cell Rev Rep
March 2025
Center for Preclinical Studies and Technology, Department of Regenerative Medicine, Warsaw Medical University, Warsaw, Poland.
The intracellular complement network, known as the complosome, regulates lymphocyte biology, which is well established. Recently, however, we demonstrated that the complosome is also expressed in hematopoietic stem/progenitor cells (HSPCs) in addition to lymphocytes. In our previous work, murine lineage-negative (Lin) bone marrow (BM) mononuclear cells (BMMNC) from mice lacking the intracellular C3 and C5 complosome proteins displayed different responses to stress.
View Article and Find Full Text PDFInflammatory reprogramming of the solid tumor microenvironment by infiltrating clonal hematopoiesis is associated with adverse outcomes.
Cell Rep Med
February 2025
Department of Pathology & Molecular Medicine, Queen's University, Kingston, ON, Canada; Department of Medicine, Queen's University, Kingston, ON, Canada. Electronic address:
Clonal hematopoiesis (CH)-the expansion of somatically mutated hematopoietic cells-is common in solid cancers. CH is associated with systemic inflammation, but its impact on tumor biology is underexplored. Here, we report the effects of CH on the tumor microenvironment (TME) using 1,550 treatment-naive patient samples from the Clinical Proteomics Tumor Analysis Consortium (CPTAC) cohort.
View Article and Find Full Text PDFComparative Profiling of Regulatory Modules as a Tool for Identifying the Transcription Factor Network Linked to Leukemogenesis.
Methods Mol Biol
March 2025
Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
The dynamic gene expression program of hematopoiesis is controlled by a complex network of regulatory modules consisting of transcription factors, chromatin modifiers, and genomic organizers. Genetic abnormalities or changes in the levels of these factors can disrupt normal development and often lead to malignant transformation into leukemic cells. Open chromatin regions are hallmarks of regulatory elements that can be profiled by their susceptibility to DNase I and Tn5 transposase.
View Article and Find Full Text PDFRomiplostim in Aplastic Anemia: A Single-Center Retrospective Study.
Cureus
January 2025
Hematology, Anjali Diagnostic Laboratory, Genepath Pathology, Mumbai, IND.
Background Acquired aplastic anemia (AA) is an immune-mediated hematopoietic disorder. It is characterized by pancytopenia and hypocellular bone marrow. The first-line treatment approach to AA includes immunosuppressive treatment (IST) using the combination of antithymocyte globulin (ATG) and cyclosporine A.
View Article and Find Full Text PDFMetabolic alterations in HSCs during aging and leukemogenesis.
Physiology (Bethesda)
February 2025
Department of Oncology, Ludwig Institute for Cancer Research, University of Lausanne; 1066 Epalinges, Switzerland.
Aging is a multifaceted process associated with a functional decline in cellular function over time, affecting all lifeforms. During the aging process, metabolism, a fundamental hallmark of life (1), is profoundly altered. In the context of hematopoiesis, the proper function of hematopoietic stem cells - at the apex of the blood system - is tightly linked to their energy metabolism, which in turn shapes hematopoietic output.
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