Novel insights into mA modification of coding and non-coding RNAs in tumor biology: From molecular mechanisms to therapeutic significance.

Accumulating evidence has revealed that mA modification, the predominant RNA modification in eukaryotes, adds a novel layer of regulation to the gene expression. Dynamic and reversible mA modification implements sophisticated and crucial functions in RNA metabolism, including generation, splicing, stability, and translation in messenger RNAs (mRNAs) and non-coding RNAs (ncRNAs). Furthermore, mA modification plays a determining role in producing various mA-labeling RNA outcomes, thereby affecting several functional processes, including tumorigenesis and progression. Herein, we highlighted current advances in mA modification and the regulatory mechanisms underlying mRNAs and ncRNAs in distinct cancer stages. Meanwhile, we also focused on the therapeutic significance of mA regulators in clinical cancer treatment.