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Engineering hydrogen bonding at tyrosine-201 in the orange carotenoid protein using halogenated analogues.
Photosynth Res
January 2025
Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia.
The Orange Carotenoid Protein (OCP) is a unique water-soluble photoactive protein that plays a critical role in regulating the balance between light harvesting and photoprotective responses in cyanobacteria. The challenge in understanding OCP´s photoactivation mechanism stems from the heterogeneity of the initial configurations of its embedded ketocarotenoid, which in the dark-adapted state can form up to two hydrogen bonds to critical amino acids in the protein's C-terminal domain, and the extremely low quantum yield of primary photoproduct formation. While a series of experiments involving point mutations within these contacts helped us to identify these challenges, they did not resolve them.
View Article and Find Full Text PDFUsing predictive models to identify kelp refuges in marine protected areas for management prioritization.
Ecol Appl
January 2025
Parks Victoria, Marine and Coastal Science and Programs, Melbourne, Victoria, Australia.
Kelp forests serve as the foundation for shallow marine ecosystems in many temperate areas of the world but are under threat from various stressors, including climate change. To better manage these ecosystems now and into the future, understanding the impacts of climate change and identifying potential refuges will help to prioritize management actions. In this study, we use a long-term dataset of observations of kelp percentage cover for two dominant canopy-forming species off the coast of Victoria, Australia: Ecklonia radiata and Phyllospora comosa.
View Article and Find Full Text PDFPhytochemical analysis of dried ginger extract and its inhibitory effect and mechanism on and associated ureases.
Food Funct
January 2025
Department of Pharmacology, Zunyi Medical University, Zhuhai Campus, Zhuhai 519041, PR China.
(), one of the most common infectious pathogens in the world, can cause gastritis, digestive ulcers, and even gastric cancer. urease (HPU) is a distinctive virulence factor of that allows it to be distinguished from other pathogens. Dried ginger is a famous edible and medicinal herb that is commonly used to prevent and treat gastrointestinal tract-related diseases.
View Article and Find Full Text PDFAdvances in Selenium and Related Compounds Inhibiting Multi-Organ Fibrosis.
Drug Des Devel Ther
January 2025
Hubei Selenium and Human Health Institute, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, 445000, People's Republic of China.
Selenium (Se), a critically essential trace element, plays a crucial role in diverse physiological processes within the human body, such as oxidative stress response, inflammation regulation, apoptosis, and lipid metabolism. Organ fibrosis, a pathological condition caused by various factors, has become a significant global health issue. Numerous studies have demonstrated the substantial impact of Se on fibrotic diseases.
View Article and Find Full Text PDFTherapeutic Potential of Crocin and Nobiletin in a Mouse Model of Dry Eye Disease: Modulation of the Inflammatory Response and Protection of the Ocular Surface.
Iran J Pharm Res
September 2024
Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Background: Dry eye disease (DED) is a multifactorial condition characterized by ocular surface inflammation, tear film instability, and corneal epithelial damage. Current treatments often provide temporary relief without addressing the underlying inflammatory mechanisms.
Objectives: This study examined the therapeutic potential of crocin and nobiletin, two naturally derived compounds with well-known antioxidant and anti-inflammatory properties, in a mouse model of DED induced by lacrimal gland excision (LGE).
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