AI Article Synopsis
- Diabetes leads to serious heart issues like coronary artery disease and diabetic cardiomyopathy, but it also disrupts the heart's electrical system, increasing the risk of dangerous arrhythmias and sudden cardiac death.
- Arrhythmias related to diabetes are influenced by more than just reduced blood flow or nerve damage; changes in blood sugar levels (both low and high) can trigger these heart rhythm problems through various biological pathways.
- Structural changes in heart tissue and issues with cell energy production can worsen these conditions, as they promote inflammation and oxidative stress that further compromise heart health.
Article Abstract
Coronary artery disease, autonomic neuropathy, and diabetic cardiomyopathy are the most common cardiovascular complications of diabetes. However, emerging evidence demonstrates that diabetes also affects the heart's electrical conduction system, culminating in lethal arrhythmias and sudden cardiac death. Diabetes and rhythm disturbances have a complex relationship, and arrhythmias cannot only be attributed to ischemia and autonomic neuropathy. Hypoglycemia, hyperglycemia, and glucose fluctuations can potentially induce arrhythmias by activating various pathways. Structural remodeling can accelerate and exacerbate disease development. Mitochondrial dysfunction can also alter the structure and metabolism of cardiomyocytes and contribute to disease progression through oxidative stress and inflammation.
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| http://dx.doi.org/10.2174/1381612828666220720095433 | DOI Listing |
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