The aim of this study was to estimate the associations of blood manganese and selenium with serum concentrations of selected perfluoroalkyl substances (PFAS). The presence or absence of this association is important because PFAS have documented pro-oxidant properties, whereas manganese and selenium are critical to antioxidant responses. For this purpose, the data from NHANES for US adults aged ≥ 20 years (N = 3982), adolescents aged 12-19 years (N = 1524), and children aged 3-11 years (N = 639) were analyzed. Among adults, concentrations of blood manganese were found to be inversely associated with serum concentrations of perfluorooctanoic acid or PFOA (β = - 0.04204, p < 0.01), perfluorononanoic acid or PFNA (β = - 0.02700, p < 0.01), perfluorohexane sulfonate or PFHxS (β = - 0.04306, p < 0.01), and perfluorooctane sulfonate or PFOS (β = - 0.04494, p < 0.01). Blood concentrations of selenium were found to be positively associated with PFHxS only among adults (β = 0.000678, p = 0.047) and adolescents (β = 0.01377, p = 0.02). The Mn results but not the less consistent Se associations were robust to adjustments for serum albumin. Possible reasons for the inverse association of PFOA, PFHxS, PFNA, and PFOS with Mn among US adults are discussed. The finding raises concerns about manganese's diminished ability to mount antioxidant responses to PFAS exposure.
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