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A nationwide questionnaire study of post-acute symptoms and health problems after SARS-CoV-2 infection in Denmark. | LitMetric

AI Article Synopsis

  • A large study in Denmark found that many people who tested positive for SARS-CoV-2 continue to have lingering symptoms six to twelve months after their infection.
  • Among the 61,002 confirmed cases, the most significant ongoing issues included loss of smell (dysosmia), loss of taste (dysgeusia), fatigue, shortness of breath (dyspnea), and reduced strength in limbs.
  • Women and middle-aged individuals were noted to have a higher risk of experiencing these prolonged symptoms, including new diagnoses of anxiety and depression during the study period.

Article Abstract

A considerable number of individuals infected with SARS-CoV-2 continue to experience symptoms after the acute phase. Here, we report findings from a nationwide questionnaire study in Denmark including 61,002 RT-PCR confirmed SARS-CoV-2 cases and 91,878 test-negative controls aged 15-years or older. Six to twelve months after the test, the risks of 18 out of 21 symptoms were elevated among test-positives. The largest adjusted risk differences (RD) were observed for dysosmia (RD = 10.92%, 95% CI 10.68-11.21%), dysgeusia (RD = 8.68%, 95% CI 8.43-8.93%), fatigue/exhaustion (RD = 8.43%, 95%CI 8.14-8.74%), dyspnea (RD = 4.87%, 95% CI 4.65-5.09%) and reduced strength in arms/legs (RD = 4.68%, 95% CI 4.45-4.89%). During the period from the test and until completion of the questionnaire, new diagnoses of anxiety (RD = 1.15%, 95% CI 0.95-1.34%) or depression (RD = 1.00%, 95% CI 0.81-1.19%) were also more common among test-positives. Even in a population where the majority of test-positives were not hospitalized, a considerable proportion experiences symptoms up to 12 months after infection. Being female or middle-aged increases risks.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9302226PMC
http://dx.doi.org/10.1038/s41467-022-31897-xDOI Listing

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