Background: Elevated lipoprotein(a) (Lp[a]) levels are an independent risk factor for the development of atherosclerotic diseases, including peripheral artery disease (PAD). However, their prognostic impact in patients with PAD remains unknown.
Objectives: The aim of this study was to examine the prognostic impact of elevated Lp(a) levels in patients with PAD undergoing endovascular therapy (EVT).
Methods: In total, 1,169 patients who underwent successful EVT for symptomatic PAD between September 2016 and August 2021 were included in this study. High Lp(a) levels were defined as >30 mg/dL. The associations of high Lp(a) levels with incident major adverse cardiovascular events (MACE) (all-cause death, myocardial infarction, and stroke) and major adverse limb events (MALE) (repeat revascularization for target limb and major amputation) were analyzed.
Results: During a median follow-up period of 1.7 years (IQR: 0.6-3.0 years), 230 MACE (210 deaths, 15 myocardial infarctions, and 22 strokes) and 263 MALE (219 reinterventions and 36 major amputations) were observed. The cumulative incidence rate of MACE (48.1% vs 27.3%) and MALE (67.9% vs 27.2%) was significantly higher in patients with high Lp(a) levels (P < 0.001 for both). The adjusted HR were 1.93 (95% CI: 1.44-2.59; P < 0.001) for MACE and 4.15 (95% CI: 3.14-5.50; P < 0.001) for MALE. These associations were not influenced by low-density lipoprotein cholesterol levels or statin administration (P for interaction >0.05 for all).
Conclusions: Elevated Lp(a) levels were independently associated with incident MACE and MALE in patients with PAD treated with revascularization irrespective of low-density lipoprotein cholesterol level and statin administration.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jcin.2022.05.050 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Identifying subgroups of individuals based on their epistemic stance, attachment dimensions and childhood trauma: A latent profile analysis.
J Psychiatr Res
December 2024
Research Department of Clinical, Educational and Health Psychology, University College London, London, United Kingdom; Anna Freud National Centre for Children and Families, London, United Kingdom.
Background: The present study examines the interplay between epistemic stance, attachment dimensions, and childhood trauma in relation to specific demographic factors and mental health outcomes. This study aims to understand how these factors form distinct profiles among individuals, to identify those at risk of mental health concerns.
Method: Latent Profile Analysis (LPA) was employed on a dataset from the general population (n = 500) to identify subgroups of individuals based on their epistemic stance (mistrust and credulity), attachment dimensions, and childhood trauma.
Clinical Manifestations.
Alzheimers Dement
December 2024
Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Background: Although it is well established that lower cognitive performance, on average, is associated with a greater risk of developing Alzheimer's disease (AD) dementia, it is unclear whether distinct cognitively-defined subgroups exist among non-demented older adults and whether such profiles map onto distinct AD neuroimaging measure profiles.
Method: The sample consisted of 167 non-demented older adults from the BIOCARD study with comprehensive neuropsychological and clinical evaluations, amyloid PET and brain MRI scans. The MRI measure included: global cortical volume in AD-signature regions and a medial-temporal lobe composite; resting-state functional connectivity within 5 large-scale cognitive networks; global white matter microstructure, index by fractional anisotropy (FA) and radial diffusion (RD) on DTI scans; and global white matter hyperintensity (WMH) volume on FLAIR scans.
Clinical Manifestations.
Alzheimers Dement
December 2024
Division of Psychiatry, University College London, London, United Kingdom.
Background: Psychological factors such as repetitive negative thinking, proneness to experience distress, and perceived stress are associated with increased risk of neurodegeneration and clinical dementia, whereas having a sense of life-purpose, self-reflection, and dispositional mindfulness may be protective. However, whether combinations of these risk and protective factors may inform distinct psychological profiles, which may be differential associated with age-related health outcomes is currently unknown.
Method: We included 742 middle-aged (mean age 51.
HPV-Associated Gene Signatures in Bladder Cancer: A Comprehensive Prognostic Model and its Implications in Immunotherapy.
Int J Med Sci
January 2025
Department of Urology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong 518033, China.
Evidence increasingly indicates that HPV infection plays a pivotal role in the initiation and progression of bladder cancer (BC). Yet, determining the predictive value of HPV-associated genes in BC remains challenging. We identified differentially expressed HPV-associated genes of BC patients from the TCGA and GEO databases.
View Article and Find Full Text PDFPretreatment Lipoprotein(a) as a Biomarker for EGFR Mutation and Prognosis in Lung Adenocarcinoma.
Int J Gen Med
December 2024
Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, People's Republic of China.
Article Synopsis
- This study explores the relationship between pretreatment serum lipoprotein(a) [Lp(a)] levels and EGFR gene mutations in patients with advanced lung adenocarcinoma undergoing treatment with EGFR-TKIs.
- The research evaluated 338 patients and concluded that a higher Lp(a) level (above 20.48 mg/L) is linked to a lower rate of EGFR mutations (48.0% vs 65.5%).
- The findings also indicate that higher Lp(a) levels are associated with longer progression-free survival (16.1 months vs 9.6 months), suggesting it is a significant independent predictor for both EGFR mutations and PFS.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!