AI Article Synopsis
- This study focuses on improving dialysis membranes to better resist protein fouling and promote biocompatibility to address health issues related to dialysis, such as various vascular diseases.
- It examines polysulfone (PSF)-based membranes, highlighting their properties like flow rate and solute clearance, and discusses advancements in commercially available options.
- The goal is to develop high flux PSF membranes that minimize oxidative stress and stabilize blood pressure, addressing the growing demand for more effective and safer dialysis solutions.
Article Abstract
The focus of this study is to enhance the protein fouling resistance, hydrophilicity, biocompatibility, hemocompatibility and ability of the membranes and to reduce health complications like chronic pulmonary disease, peripheral vascular disease, cerebrovascular disease, and cardiovascular disease after dialysis, which are the great challenges in HD applications. In the current study, the PSF-based dialysis membranes are studied broadly. Significant consideration has also been provided to membrane characteristics (e.g., flowrate coefficient, solute clearance characteristic) and also on commercially available polysulfone HD membranes. PSF has gained a significant share in the development of HD membranes, and continuous improvements are being made in the process to make high flux PSF-based dialysis membranes with enhanced biocompatibility and improved protein resistance ability as the major issue in the development of membranes for HD application is biocompatibility. There has been a great increase in the demand for novel biocompatible membranes that offer the best performances during HD therapy, for example, low oxidative stress and low change ability of blood pressure.
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| http://dx.doi.org/10.1016/j.chemosphere.2022.135626 | DOI Listing |
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