The need for speed: Migratory cells in tight spaces boost their molecular clock.

Cell Syst

School of Engineering, Center for Biomedical Engineering, and Legoretta Cancer Center, Brown University, Providence, RI 02912, USA. Electronic address:

Published: July 2022

Cells migrating in spatial confinement exhibit higher intracellular calcium levels, which increases the oscillation frequency of a "molecular clock" that synchronizes guanine nucleotide exchange factor GEF-H1 and microtubule polymerization for more frequent bursts of speed.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071288PMC
http://dx.doi.org/10.1016/j.cels.2022.06.002DOI Listing

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