Cells migrating in spatial confinement exhibit higher intracellular calcium levels, which increases the oscillation frequency of a "molecular clock" that synchronizes guanine nucleotide exchange factor GEF-H1 and microtubule polymerization for more frequent bursts of speed.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071288 | PMC |
http://dx.doi.org/10.1016/j.cels.2022.06.002 | DOI Listing |
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