AI Article Synopsis

  • The CMMG model simulates bladder mechanics and micturition while adapting to changes in biomechanical conditions, specifically focusing on bladder growth and remodeling in response to partial bladder outlet obstruction (BOO).
  • Calibrated with data from healthy male rat bladders, the model accounts for both immediate voiding mechanics and long-term tissue adaptations.
  • It predicts significant changes in bladder function and structure due to BOO, including voiding capacity loss, muscle growth, collagen remodeling, and variations in voiding duration, highlighting its potential use in developing treatments for bladder diseases.

Article Abstract

We present a constrained mixture-micturition-growth (CMMG) model for the bladder. It simulates bladder mechanics, voiding function (micturition) and tissue adaptations in response to altered biomechanical conditions. The CMMG model is calibrated with both in vivo and in vitro data from healthy male rat urinary bladders (cystometry, bioimaging of wall structure, mechanical testing) and applied to simulate the growth and remodeling (G&R) response to partial bladder outlet obstruction (BOO). The bladder wall is represented as a multi-layered, anisotropic, nonlinear constrained mixture. A short time scale micturition component of the CMMG model accounts for the active and passive mechanics of voiding. Over a second, longer time scale, G&R algorithms for the evolution of both cellular and extracellular constituents act to maintain/restore bladder (homeostatic) functionality. The CMMG model is applied to a spherical membrane model of the BOO bladder utilizing temporal data from an experimental male rodent model to parameterize and then verify the model. Consistent with the experimental studies of BOO, the model predicts: an initial loss of voiding capacity followed by hypertrophy of SMC to restore voiding function; bladder enlargement; collagen remodeling to maintain its role as a protective sheath; and increased voiding duration with lower average flow rate. This CMMG model enables a mechanistic approach for investigating the bladder's structure-function relationship and its adaption in pathological conditions. While the approach is illustrated with a conceptual spherical bladder model, it provides the basis for application of the CMMG model to anatomical geometries. Such a mechanistic approach has promise as an in silico tool for the rational development of new surgical and pharmacological treatments for bladder diseases such as BOO.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835014PMC
http://dx.doi.org/10.1016/j.jmbbm.2022.105337DOI Listing

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