AI Article Synopsis
- - Ovarian immature teratoma (IT) is a rare germ cell tumor that can have varying components and is graded mainly by its neuroectodermal content, which complicates diagnosis and treatment options.
- - IT may show somatic differentiation, potentially leading to other malignancies and can result in low levels of serum alpha-fetoprotein, leading to differing opinions in management between pediatric and adult cases.
- - The Malignant Germ Cell International Consortium (MaGIC) gathered experts to discuss critical issues such as grading, the role of yolk sac tumors, transformations to somatic cancers, and serum tumor markers, resulting in guidelines for better management of IT.
Article Abstract
Ovarian immature teratoma is a rare subtype of germ cell tumour that can be pure or associated with non-teratomatous germ cell tumour elements and is graded based on extent of the immature neuroectodermal component. Immature teratoma (IT) can also be associated with somatic differentiation in the form of sarcoma, carcinoma, or extensive immature neuroectodermal elements and may produce low levels of serum alpha-fetoprotein. Variable interpretation of these issues underlies diagnostic and management dilemmas, resulting in substantial practice differences between paediatric and adult women with IT. The Malignant Germ Cell International Consortium (MaGIC) convened oncologists, surgeons, and pathologists to address the following crucial clinicopathologic issues related to IT: (1) grading of IT, (2) definition and significance of 'microscopic' yolk sac tumour, (3) transformation to a somatic malignancy, and (4) interpretation of serum tumour biomarkers. This review highlights the discussion, conclusions, and suggested next steps from this clinicopathologic conference.
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| http://dx.doi.org/10.1016/j.ejca.2022.06.006 | DOI Listing |
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