Herein, we report the first general C(sp)-C(sp) reductive cross-coupling reaction of diverse triarylphosphines with a wide range of aryl halides by palladium/nickel co-catalysis. This protocol offers a unique route for the synthesis of biaryl compounds via the activation of inert C(Ar)-P bonds. The mechanistic studies demonstrate that the formation of the phosphonium salts in situ plays a key role in the catalytic cycle.
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| http://dx.doi.org/10.1021/acs.orglett.2c02139 | DOI Listing |
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