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| http://dx.doi.org/10.1161/JAHA.122.026798 | DOI Listing |
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The cell-permeant antioxidant D-thiol ester D-cysteine ethyl ester overcomes physical dependence to morphine in male Sprague Dawley rats.
Front Pharmacol
August 2024
Department of Pediatrics, Case Western Reserve University, Cleveland, OH, United States.
The ability of morphine to decrease cysteine transport into neurons by inhibition of excitatory amino acid transporter 3 (EAA3) may be a key molecular mechanism underlying the acquisition of physical and psychological dependence to morphine. This study examined whether co-administration of the cell-penetrant antioxidant D-thiol ester, D-cysteine ethyl ester (D-CYSee), with morphine, would diminish the development of physical dependence to morphine in male Sprague Dawley rats. Systemic administration of the opioid receptor antagonist, naloxone (NLX), elicited pronounced withdrawal signs (e.
View Article and Find Full Text PDFL-cysteine ethyl ester prevents and reverses acquired physical dependence on morphine in male Sprague Dawley rats.
Front Pharmacol
December 2023
Department of Pediatrics, Case Western Reserve University, Cleveland, OH, United States.
The molecular mechanisms underlying the acquisition of addiction/dependence on morphine may result from the ability of the opioid to diminish the transport of L-cysteine into neurons via inhibition of excitatory amino acid transporter 3 (EAA3). The objective of this study was to determine whether the co-administration of the cell-penetrant L-thiol ester, L-cysteine ethyl ester (L-CYSee), would reduce physical dependence on morphine in male Sprague Dawley rats. Injection of the opioid-receptor antagonist, naloxone HCl (NLX; 1.
View Article and Find Full Text PDFWhole-body analysis of TRPML3 (MCOLN3) expression using a GFP-reporter mouse model reveals widespread expression in secretory cells and endocrine glands.
PLoS One
December 2022
Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany.
Article Synopsis
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Circling In on Pulmonary Arterial Hypertension: Is It Time to Consider Circular RNA circ_0016070 as a Biomarker and Target for Therapy?
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Division of Pulmonary, Critical Care and Sleep Medicine, Lung Center University of California, Davis School of Medicine Davis CA.
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