Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1001/jamaophthalmol.2022.2166 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pemafibrate Induces a Low Level of PPARα Agonist-Stimulated mRNA Expression of ANGPTL4 in ARPE19 Cell.
Bioengineering (Basel)
December 2024
Departments of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University, S1W17, Chuo-ku, Sapporo 060-8556, Japan.
To elucidate the unidentified roles of a selective peroxisome proliferator-activated receptor α (PPARα) agonist, pemafibrate (Pema), on the pathogenesis of retinal ischemic diseases (RID)s, the pharmacological effects of Pema on the retinal pigment epithelium (RPE), which is involved in the pathogenesis of RID, were compared with the pharmacological effects of the non-fibrate PPARα agonist GW7647 (GW). For this purpose, the human RPE cell line ARPE19 that was untreated (NT) or treated with Pema or GW was subjected to Seahorse cellular metabolic analysis and RNA sequencing analysis. Real-time cellular metabolic function analysis revealed that pharmacological effects of the PPARα agonist actions on essential metabolic functions in RPE cells were substantially different between Pema-treated cells and GW-treated cells.
View Article and Find Full Text PDFSingle-cell analysis of the epigenome and 3D chromatin architecture in the human retina.
bioRxiv
December 2024
Department of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA 92037, USA.
Most genetic risk variants linked to ocular diseases are non-protein coding and presumably contribute to disease through dysregulation of gene expression, however, deeper understanding of their mechanisms of action has been impeded by an incomplete annotation of the transcriptional regulatory elements across different retinal cell types. To address this knowledge gap, we carried out single-cell multiomics assays to investigate gene expression, chromatin accessibility, DNA methylome and 3D chromatin architecture in human retina, macula, and retinal pigment epithelium (RPE)/choroid. We identified 420,824 unique candidate regulatory elements and characterized their chromatin states in 23 sub-classes of retinal cells.
View Article and Find Full Text PDFDo Patients With Candidemia Need an Ophthalmologic Examination?
Open Forum Infect Dis
December 2024
Division of Infectious Diseases and International Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Background: The Infectious Diseases Society of America recommends a screening dilated retinal examination by an ophthalmologist for all patients with candidemia. Conversely, the American Academy of Ophthalmology recommends against routine screening in patients with candidemia without symptoms.
Methods: In a collaborative effort between infectious diseases and ophthalmology, we examined the incidence of ocular complications in 308 patients with candidemia and subsequently measured the rate of fundoscopic examinations, risk factors for ocular complications, management changes, and outcomes.
Evaluation of changes in thickness of macular sublayers in patients using Hydroxychloroquine: a cross sectional case-control study and literature review.
Cutan Ocul Toxicol
December 2024
Poostchi Ophthalmology Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Purpose: To assess changes in the thickness of macular sublayers in individuals taking hydroxychloroquine (HCQ) without any evident toxicity and to review the relevant literature.
Methods: This prospective case-control study examined 47 adults on HCQ without evident toxicity on spectral-domain optical coherence tomography (SD-OCT) and visual field tests, as well as 25 healthy controls. Macular thickness in different sublayers was measured using SD-OCT.
"Caution with choroidals" - choose the right one at right time.
Indian J Ophthalmol
December 2024
Department of Oculoplasty, Disha Eye Hospitals Pvt Ltd, Kolkata, West Bengal, India.
Article Synopsis
- Choroidal detachment (CD) during retinal detachment surgery can negatively affect surgical results and vision, necessitating specific management techniques.
- Cannula-guided choroidal drainage is essential for mitigating pre-existing CDs, especially in complex cases with hemorrhagic detachment.
- Intraoperative sudden CD can be caused by issues like hypotony or air entry from cannula slippage, which may lead to serious complications like Venous Air Embolism (VAE); prompt action to stop air infusion is critical to prevent life-threatening outcomes.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!