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The Relevance of the Virchow Node and Virchow Triad in Renal Cancer Diagnosis.
Clin Pract
January 2025
Department of Cardiology and Internal Medicine, Colțea Clinical Hospital, 030167 Bucharest, Romania.
The purpose of this article is to overview the clinical significance of left supraclavicular adenopathy and review the etiology of inferior vena cava (IVC) thrombosis, starting from a presentation of a rare case of renal cell carcinoma (RCCs) with Xp11.2 translocation involving TFE3 gene fusion. This article also aims to review the literature to understand the characteristics of this rare type of renal tumor.
View Article and Find Full Text PDFPrimary cutaneous rhabdomyosarcoma with EWSR1/FUS::TFCP2 fusion: four new cases with distinctive morphology, immunophenotypic, and genetic profile.
Virchows Arch
December 2024
Department of Pathology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
EWSR1/FUS::TFCP2-rearranged rhabdomyosarcoma (RMS) is a rare tumor with an aggressive clinical course, a predilection for craniofacial bones, spindled and/or epithelioid histomorphology, and positive immunohistochemistry (IHC) for epithelial and myogenic markers, along with variable ALK expression. Herein, we present four additional cases of primary cutaneous TFCP2-rearranged RMS. Notably, one tumor (case 1) displayed a varied pathological spectrum, initially presenting as a low-grade spindle cell neoplasm, but progressed into a high-grade spindle/epithelioid tumor.
View Article and Find Full Text PDFHeterogeneity of pancreatic neoplasms arising in pancreatic heterotopia: a single institution review.
Virchows Arch
November 2024
Department of Pathology and Immunology, Washington University in St. Louis, 660 South Euclid Avenue, Campus, Box 8118, St. Louis, MO, 63110, USA.
Article Synopsis
- Pancreatic heterotopia (PH) is when pancreatic tissue forms in the gastrointestinal tract and can have various health issues, though cancer development in PH is very uncommon.
- A study reviewed 163 PH cases from 1990 to 2020, finding that 7 had neoplastic processes, including different types of tumors.
- Most affected patients were men around 64 years old, with symptoms such as weight loss and abdominal pain, and it’s critical for pathologists to identify PH to ensure correct diagnosis and staging of potential tumors.
Endocervical adenocarcinoma with a micropapillary component: a clinicopathologic analysis in the setting of current WHO classification.
Virchows Arch
November 2024
Department of Surgical Pathology, Zhejiang Provincial Clinical Research Center for Obstetrics and Gynecology, Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, School of Medicine, Women's Hospital, Zhejiang University, Hangzhou, Zhejiang Province, China.
Article Synopsis
- The study analyzed 26 cases of endocervical adenocarcinoma with a micropapillary component (EAC-MP) among 511 adenocarcinomas to explore their clinicopathologic and molecular characteristics.
- HPV-associated micropapillary adenocarcinomas (HPVA-MP) exhibited worse clinical features including larger tumor size, higher rates of lymphovascular invasion, and poorer survival outcomes compared to those without the micropapillary component (HPVA-NMP).
- The study identified significant gene mutations and HER2 amplification in EAC-MP, suggesting potential for targeted therapies and emphasizing the micropapillary structure as a marker for unfavorable outcomes in patients.
Spitz tumours and mimickers.
Virchows Arch
November 2024
Department of Pathology, University of Texas - MD Anderson Cancer Center, Houston, TX, 77030, USA.
Since their initial description in 1948, Spitz tumours have always been a challenge in the field of dermatopathology and paediatric pathology. Advances in molecular pathology have confirmed they are associated with specific anomalies, mainly gene fusions. They display a wide range of clinical presentations and histological subtypes.
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