Impact of NB-UVB phototherapy on Caveolin-1 expression in chronic plaque psoriasis.

Photodermatol Photoimmunol Photomed

Dermatology and Venereology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

Published: May 2023

Background: Caveolin-1 (Cav-1) is a significant structural and regulatory constituent of cell membranes that has been implicated in cell kinetics and inflammation.

Objective: To assess Cav-1 expression in psoriasis before and after phototherapy.

Patients And Methods: Thirty psoriasis cases and 30 healthy controls were recruited. Cases were managed with narrow band-ultraviolet B (NB-UVB) phototherapy at frequency three times per week for 12 weeks. From every case, two biopsy specimens were gained from psoriatic lesions (pre and post phototherapy), in addition to one from apparently normal skin of psoriasis cases. Regarding the control group, one biopsy was taken from a matched site. All were studied for Cav-1 antibody immuno-expression.

Results: There was a significant decrease in Cav-1 expression in psoriatic lesions compared to both the apparently normal skin of psoriasis patients and standard control skin of healthy individuals. After NB-UVB phototherapy, significant upregulation of Cav-1 immunostaining score was observed in previously psoriatic skin when compared to that before treatment. In addition, there were significant negative correlations between Cav-1 immunostaining score and the clinical scores of psoriasis severity including; the erythema, scaling, and induration (ESI) score and the patient psoriasis area and severity index (PASI) score.

Conclusion: Induction of Cav-1 expression may be a likely pathway for the effectiveness of NB-UVB in psoriasis. Cav-1 may be a useful marker for evaluation of psoriasis severity, disease progression, and therapeutic efficacy.

Download full-text PDF

Source
http://dx.doi.org/10.1111/phpp.12822DOI Listing

Publication Analysis

Top Keywords

nb-uvb phototherapy
12
cav-1 expression
12
psoriasis
9
cav-1
8
psoriasis cases
8
psoriatic lesions
8
normal skin
8
skin psoriasis
8
cav-1 immunostaining
8
immunostaining score
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!