The family of the neurotrophic tropomyosin kinase receptors (NTRK or TRK) is a part of the transmembrane tyrosine kinases responsible for neuronal development. The members of this receptor family are TRKA, TRKB and TRKC and they are encoded by the genes , and . Alterations of genes can induce carcinogenesis both in neurogenic and non-neurogenic cells. The prevalence of gene fusion is under 1% in solid tumors, but is highly encountered in rare tumors. The presence of gene fusion is associated, in some types of neoplasia, with a favorable evolution, but the presence of NTRK 2 may be associated with a poor prognosis. The identification of cancer patients harboring gene fusions is constantly growing, especially with the advent of NTRK inhibitors. This has promisingly provided a rationale for personalized therapeutics that improved outcomes in settings with this signature.
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| http://dx.doi.org/10.1016/j.amsu.2022.103893 | DOI Listing |
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