AI Article Synopsis
- - Fever of unknown origin (FUO) is defined as a body temperature exceeding 38.3°C lasting for at least 3 weeks without a clear diagnosis after a week of standard medical evaluation.
- - Common causes of FUO include infections, blood-related diseases, autoimmune disorders, and other inflammatory conditions.
- - The use of quantitative metagenomics next-generation sequencing (Q-mNGS) has increased in recent years to help identify rare or new pathogens, aiding in the investigation of undetermined fever causes.
Article Abstract
A body temperature >38.3°C that lasts ≥3 weeks and lacks a clear diagnosis after 1 week of standard hospital examination and treatment is called "fever of unknown origin" (FUO). The main causes of FUO are infections, hematological diseases, autoimmune diseases, and other non-infectious inflammatory diseases. In recent years, quantitative metagenomics next-generation sequencing (Q-mNGS) has been used widely to detect pathogenic microorganisms, especially in the contribution of rare or new (e.g., severe acute respiratory syndrome-coronavirus-2) pathogens. This review addresses the undetermined cause of fever and its evaluation by Q-mNGS.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289621 | PMC |
| http://dx.doi.org/10.3389/fmicb.2022.931058 | DOI Listing |
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