Blue compact dwarf (BCD) galaxies are low-luminosity (absolute K-band magnitude, M > -21 mag), metal-poor (1/50 ≤ Z/Z ≤ 1/2, where Z is the metallicity in terms of the solar metallicity Z), centrally concentrated galaxies with bright clumps of star formation. Cosmological surface-brightness dimming and the small size of BCDs limit their detection at high redshifts, making their formation process difficult to observe. Observations of BCDs are needed at intermediate redshifts, where they are still young enough to show their formative stages, particularly in the outer regions where cosmic gas accretion should drive evolution. Here we report the observation of excess far-ultraviolet (FUV) emission in the outer regions of 11 BCDs in the GOODS South field at redshifts between 0.1 and 0.24, corresponding to look-back times of 1.3-2.8 billion years in standard cosmology. These observations were made by the Ultra-Violet Imaging Telescope on AstroSat. For ten BCDs, the radial profiles of the intrinsic FUV emission, corrected for the instrument point spread function, have larger scale lengths than their optical counterparts observed with the Hubble Space Telescope. Such shallow FUV profiles suggest extended star formation in cosmically accreting disks. Clumpy structure in the FUV also suggests that the outer FUV disks are gravitationally unstable. Dynamical friction on the clumps drives them inwards at an average rate exceeding 10 solar masses per billion years.
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http://dx.doi.org/10.1038/s41586-022-04905-9 | DOI Listing |
BMJ Oncol
September 2024
Department of Biochemistry, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Circulating tumour cells (CTCs) and CTC clusters are considered metastatic precursors due to their ability to seed distant metastasis. However, navigating the bloodstream presents a significant challenge for CTCs, as they must endure fluid shear forces and resist detachment-induced anoikis. Consequently, while a large number of cells from the primary tumour may enter the circulation, only a tiny fraction will result in metastasis.
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January 2025
Research and Innovation Center, Shanghai Pudong Hospital, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai, 200433, China.
Investigating plasma proteomic signatures of dementia offers insights into its pathology, aids biomarker discovery, supports disease monitoring, and informs drug development. Here, we analyzed data from 48,367 UK Biobank participants with proteomic profiling. Using Cox and generalized linear models, we examined the longitudinal associations between proteomic signatures and dementia-related phenotypes.
View Article and Find Full Text PDFPLoS One
January 2025
Biomedical Sciences Research Institute, Centre for Genomic Medicine, Ulster University, Coleraine, Northern Ireland, United Kingdom.
Pseudoexfoliation glaucoma is a severe form of secondary open angle glaucoma and is associated with activation of the TGF-β pathway by TGF-β1. MicroRNAs (miRNAs) are small non-coding RNA species that are involved in regulation of mRNA expression and translation. To investigate what glaucomatous changes occur in the trabecular meshwork and how these changes may be regulated by miRNAs, we performed a bioinformatics analysis resulting in a miRNA-mRNA interactome.
View Article and Find Full Text PDFNature
January 2025
Institute for Extra-Cutting-Edge Science and Technology Avant-Garde Research (X-star), Japan Agency for Marine-Earth Science and Technology (JAMSTEC), Yokosuka, Japan.
In subsurface methanogenic ecosystems, the ubiquity of methylated-compound-using archaea-methylotrophic methanogens-implies that methylated compounds have an important role in the ecology and carbon cycling of such habitats. However, the origin of these chemicals remains unclear as there are no known energy metabolisms that generate methylated compounds de novo as a major product. Here we identified an energy metabolism in the subsurface-derived thermophilic anaerobe Zhaonella formicivorans that catalyses the conversion of formate to methanol, thereby producing methanol without requiring methylated compounds as an input.
View Article and Find Full Text PDFJ Biol Chem
January 2025
Department of Biomedical Science, Faculty of Health and Society, Malmö University, SE-205 06 Malmö, Sweden. Electronic address:
Apolipoprotein E (APOE) is distributed across various human tissues and plays a crucial role in lipid metabolism. Recent investigations have uncovered an additional facet of APOE's functionality, revealing its role in host defense against bacterial infections. To assess the antibacterial attributes of APOE3 and APOE4, we conducted antibacterial assays using P.
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