AI Article Synopsis
- Advances in spatial profiling methods for nucleic acids and proteins are essential for creating detailed cellular maps of complex samples, from tissues to entire organisms.
- These new techniques provide omics data at nano- to microscale resolutions, helping to reveal variations among cells and the structure of complex tissues, as well as changes during development and disease.
- The potential of these spatial methods includes comprehensive organ mapping and improvements in pathology, though there are still obstacles to their widespread use in research.
Article Abstract
Improved scale, multiplexing and resolution are establishing spatial nucleic acid and protein profiling methods as a major pillar for cellular atlas building of complex samples, from tissues to full organisms. Emerging methods yield omics measurements at resolutions covering the nano- to microscale, enabling the charting of cellular heterogeneity, complex tissue architectures and dynamic changes during development and disease. We present an overview of the developing landscape of in situ spatial genome, transcriptome and proteome technologies, exemplify their impact on cell biology and translational research, and discuss current challenges for their community-wide adoption. Among many transformative applications, we envision that spatial methods will map entire organs and enable next-generation pathology.
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| http://dx.doi.org/10.1038/s41576-022-00515-3 | DOI Listing |
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