Pathobionts employ unique metabolic adaptation mechanisms to maximize their growth in disease conditions. Adherent-invasive Escherichia coli (AIEC), a pathobiont enriched in the gut mucosa of patients with inflammatory bowel disease (IBD), utilizes diet-derived L-serine to adapt to the inflamed gut. Therefore, the restriction of dietary L-serine starves AIEC and limits its fitness advantage. Here, we find that AIEC can overcome this nutrient limitation by switching the nutrient source from the diet to the host cells in the presence of mucolytic bacteria. During diet-derived L-serine restriction, the mucolytic symbiont Akkermansia muciniphila promotes the encroachment of AIEC to the epithelial niche by degrading the mucus layer. In the epithelial niche, AIEC acquires L-serine from the colonic epithelium and thus proliferates. Our work suggests that the indirect metabolic network between pathobionts and commensal symbionts enables pathobionts to overcome nutritional restriction and thrive in the gut.
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http://dx.doi.org/10.1016/j.celrep.2022.111093 | DOI Listing |
Rev Argent Microbiol
December 2024
Lab. De Biofilms Microbianos, Dept. de Microbiología, Inst. de Investigaciones Biológicas Clemente Estable, Av. Italia 3318, Montevideo, Uruguay. Electronic address:
Biofilm-associated microorganisms can cause many infections and are an important cause of resistance to several antimicrobials. The antibiotic crisis has led to a pressing need for new therapeutic tools. Ambroxol is frequently used as a mucolytic agent in respiratory diseases with increased mucus production.
View Article and Find Full Text PDFJ Infect Dev Ctries
October 2024
Clinical Center on Tuberculosis Control, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.
BMC Microbiol
November 2024
Pharmaceutical Microbiology Department, Faculty of Pharmacy, Tanta University, Tanta, 31527, Egypt.
Clin Oral Investig
November 2024
Department for Biomedical and Neuromotor Sciences, DIBINEM, University of Bologna, Via San Vitale 59, 40125, Bologna, Italy.
PeerJ
October 2024
Department of Restorative Dentistry, Endodontics Division, Institute of Science and Technology, Campus of São José dos Campos, São Paulo State University (ICT-Unesp), São José dos Campos, São Paulo, Brazil.
Background: The management of endodontic infections is a complex challenge, mainly due to the involvement of diverse microorganisms and their by-products. This study aimed to evaluate the efficacy of N-acetylcysteine (NAC), calcium hydroxide (Ca(OH)), and their combined application as intracanal medications in combating , , and lipopolysaccharides (LPS) from .
Methods: A total of 60 single-rooted human teeth were carefully selected and divided into six groups.
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