Do ancient microbial irritants offer early life protection against diabetes?
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Common Bed Bugs: Non-Viable Hosts for Parasites.
Cells
December 2024
Department of Biological Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
The hemoflagellate parasite is transmitted by triatomine kissing bugs and may co-infect humans together with its Chagas disease-causing congener . Using real-time quantitative polymerase chain reaction (RT-qPCR) and antimicrobial assays, we studied () the temporal and spatial distribution of in common bed bugs, , following oral ingestion and hemocoelic injection of and () the immune responses of bed bugs induced by infections. Irrespective of infection mode, no live were present in the bed bugs' hemolymph, salivary glands, or feces.
View Article and Find Full Text PDFFrom bugs to brain: unravelling the GABA signalling networks in the brain-gut-microbiome axis.
Brain
December 2024
School of Pharmacy & Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, UK.
Convergent data, across species, paint a compelling picture of the critical role of the gut and its resident microbiota in several brain functions and disorders. The chemicals mediating communication along these sophisticated highways of the brain-gut-microbiome (BGM) axis include both microbiota metabolites and classical neurotransmitters. Amongst the latter, GABA is fundamental to brain function where it mediates the majority of neuronal inhibition.
View Article and Find Full Text PDFImprinting of the paternal marsupial X chromosome by DNA methylation.
Trends Genet
January 2025
Department of Environment and Genetics, La Trobe University, Melbourne, VIC 3168, Australia. Electronic address:
Why is it that the X chromosome that comes from the male parent is inactivated in female marsupials, female mice, and even female mealy bugs, or the whole paternal chromosome complement in some weird flies? A new paper by Milton et al. now reveals DNA methylation patterns established in the male germline before meiosis in wallabies that may constitute the elusive paternal imprint.
View Article and Find Full Text PDFTcCARP3 modulates compartmentalized cAMP signals involved in osmoregulation, infection of mammalian cells, and colonization of the triatomine vector in the human pathogen .
bioRxiv
November 2024
Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221-006, United States of America.
is the causative agent of Chagas disease, a zoonotic infectious disease considered a leading cause of cardiomyopathy, disability, and premature death in the Americas. This parasite spends its life between a mammalian host and an arthropod vector, undergoing essential transitions among different developmental forms. How senses microenvironmental changes that trigger cellular responses necessary for parasite survival has remained largely unknown.
View Article and Find Full Text PDFBugs on Drugs: Paracetamol Exposure Reveals Genotype-Specific Generational Effects on Life History Traits in .
Insects
October 2024
Department of Biology, Aarhus University, 8000 Aarhus C, Denmark.
Few investigations have been made to determine whether pharmaceutical drugs cause any generational effects. These effects can be divided into intergenerational and transgenerational effects. In insects, the F1 offspring of exposed individuals are considered to show intergenerational effects (as they have been exposed as germ cells or early embryos), while the F2 generation is fully non-exposed and considered to show transgenerational effects.
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