The standard model axion seesaw Higgs portal inflation (SMASH) model is a well-motivated, self-contained description of particle physics that predicts axion dark matter particles to exist within the mass range of 50 to 200 micro-electron volts. Scanning these masses requires an axion haloscope to operate under a constant magnetic field between 12 and 48 gigahertz. The ORGAN (Oscillating Resonant Group AxioN) experiment (in Perth, Australia) is a microwave cavity axion haloscope that aims to search the majority of the mass range predicted by the SMASH model. Our initial phase 1a scan sets an upper limit on the coupling of axions to two photons of ∣∣ ≤ 3 × 10 per giga-electron volts over the mass range of 63.2 to 67.1 micro-electron volts with 95% confidence interval. This highly sensitive result is sufficient to exclude the well-motivated axion-like particle cogenesis model for dark matter in the searched region.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258816 | PMC |
http://dx.doi.org/10.1126/sciadv.abq3765 | DOI Listing |
Alzheimers Dement
December 2024
Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Background: The 18F-AV-1451 radioligand enables in-vivo identification of tau neurofibrillary tangles that are considered as biomarkers of neurodegeneration in Alzheimer Disease (AD). However, off-target radioligand binding is also observed in basal ganglia, known as an iron-rich region. Hence, it is important to distinguish between radioligand-identified tissue neurodegeneration and iron-related radioligand binding effects.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Background: AD is defined by cortical amyloid-β (Aβ), tau neurofibrillary tangles, and neurodegeneration, pathological processes which may contribute to cognitive decline by altering large scale functional brain networks. To test this hypothesis, we examined whether plasma biomarkers of AD pathology (Aβ, phosphorylated tau [pTau-181]), astrogliosis (glial fibrillary acidic protein [GFAP]), and neuronal injury (neurofilament light chain [NfL]) related to longitudinal changes in resting-state functional connectivity (rsFC) in cognitively unimpaired participants from the Baltimore Longitudinal Study of Aging.
Method: Baseline plasma biomarkers were measured with Quanterix SIMOA assays.
Background: Robust methods are needed for preclinical evaluation of novel Alzheimer Disease (AD) therapies to accelerate drug discovery. Quantitative Gradient Recalled Echo (qGRE) MRI shows significant promise to provide insight into neurodegeneration in AD prior to atrophy development in humans, with qGRE R2t* metric (tissue-specific subcomponent of R2*) highlighting areas of low neuronal density (doi:10.3233/JAD-210503).
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Washington University, St. Louis, MO, USA.
Background: Robust methods are needed for preclinical evaluation of novel Alzheimer Disease (AD) therapies to accelerate drug discovery. Quantitative Gradient Recalled Echo (qGRE) MRI shows significant promise to provide insight into neurodegeneration in AD prior to atrophy development in humans, with qGRE R2t* metric (tissue-specific subcomponent of R2*) highlighting areas of low neuronal density (doi:10.3233/JAD-210503).
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Background: The 18F-AV-1451 radioligand enables in-vivo identification of tau neurofibrillary tangles that are considered as biomarkers of neurodegeneration in Alzheimer Disease (AD). However, off-target radioligand binding is also observed in basal ganglia, known as an iron-rich region. Hence, it is important to distinguish between radioligand-identified tissue neurodegeneration and iron-related radioligand binding effects.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!