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Congenital Titinopathy: Comprehensive Characterization of the Most Severe End of the Disease Spectrum.
Ann Neurol
January 2025
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia.
Unlabelled: Congenital titinopathy has recently emerged as one of the most common congenital muscle disorders.
Objective: To better understand the presentation and clinical needs of the under-characterized extreme end of the congenital titinopathy severity spectrum.
Methods: We comprehensively analyzed the clinical, imaging, pathology, autopsy, and genetic findings in 15 severely affected individuals from 11 families.
Mapping Trends Regarding the Cardiopulmonary Resuscitation: A Bibliometric Analysis of the Top 100 Cited Articles.
Emerg Med Int
January 2025
Department of Emergency Medicine, Etlik City Hospital, Ankara, Turkey.
Despite significant medical and technological advancements, cardiac arrest remains a critical public health concern due to its persistently high mortality and morbidity rates. Consequently, research on cardiopulmonary resuscitation (CPR) is of significant importance. This study presents a bibliometric analysis of the 100 most-cited articles in the field of CPR identified using the Scopus database without time restrictions.
View Article and Find Full Text PDFIs methamphetamine blood concentration in emergency department patients associated with the clinical picture?
Addiction
January 2025
Centre for Clinical Research in Emergency Medicine, Harry Perkins Institute of Medical Research, Perth, Australia.
Aims: This study aimed to describe clinical features and outcomes of patients presenting to the emergency department with analytically confirmed methamphetamine intoxication, to determine the blood concentration of methamphetamine and to test its association with clinical findings.
Design: The Western Australian Illicit Substance Evaluation (WISE) study is a prospective observational cohort study.
Setting: Royal Perth Hospital Emergency Department, Perth, Australia, between 2016 and 2018.
Polymeric Anti-Antibiotic Microparticles to Prevent Antibiotic Resistance Evolution.
Small
January 2025
Department of Chemical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
Vancomycin (VAN) and daptomycin (DAP) are among the last-resort antibiotics for treating multidrug-resistant Gram-positive bacterial infections. They are administered intravenously (IV); however, ≈5 - 10% of the total IV dose is released in the gastrointestinal (GI) tract via biliary excretion, driving resistance emergence in commensal Enterococcus faecium (E. faecium) populations.
View Article and Find Full Text PDFA Guide to Breast Cancer Research: An Introduction.
Adv Exp Med Biol
January 2025
Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.
"A Guide to Breast Cancer Research: From Cells and Molecular Mechanisms to Therapy" is designed as a comprehensive reference for early career investigators and postgraduate students. This book aims to provide a broad overview of contemporary breast cancer research. It covers key areas including development and cancer, metastasis and immunology, subtypes, signalling, therapy, and resistance.
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