AI Article Synopsis
- The study explores the impact of a multi-strain probiotic combined with dietary and lifestyle changes on women with polycystic ovary syndrome (PCOS), focusing on various health markers.
- The research involved 104 participants who took either probiotics or a placebo for 6 months, with assessments made on factors like menstrual cycle regularity, hormonal levels, weight, and quality of life.
- Results showed that the probiotic group experienced significant improvements in menstrual regularity, hormone levels, and quality of life, indicating that this approach could be effective for managing PCOS.
Article Abstract
Purpose: Effect of multi-strain probiotic along with dietary and lifestyle modifications in the management of polycystic ovary syndrome (PCOS) has rarely been reported. We thus aimed to investigate the effect of multi-strain probiotic (Lactobacillus acidophilus UBLA-34, L. rhamnosus UBLR-58, L. reuteri UBLRu-87 (each of 2 billion colony forming units (CFU)); L. plantarum UBLP-40, L. casei UBLC-42, L. fermentum UBLF-31, Bifidobacterium bifidum UBBB-55 (each of 1 billion CFU) and fructo-oligosaccharides (100 mg)) and dietary and lifestyle modifications on restoration of menstrual regularity, weight reduction, metabolic and hormonal profile in women with PCOS.
Methods: A 104 participants (age 18-40 years) were randomly allocated to receive probiotic or placebo capsules for 6 months. Baseline and end line assessment were performed for menstrual cycle regularity, ultrasonography scan for ovaries, total testosterone, dehydroepiandrosterone (DHEAS), insulin, luteinizing hormone/follicle stimulating hormone (LH/FSH) ratio, fasting blood sugar (FBS), homeostatic model assessment-insulin resistance (HOMA-IR), weight reduction, waist-/hip circumference (WC, HC), waist to hip ratio (WHR), and body mass index (BMI). Plasma lipopolysaccharide and effect of intervention on quality of life was investigated. Diet and exercise were controlled during the trial.
Results: Probiotic supplement along with dietary and lifestyle modifications significantly regularised menstrual cycle (p 0.023), improved levels of total testosterone (p 0.043), WC (p 0.030), WHR (p 0.027) and menstrual domain of quality of life (p 0.034) as compared to placebo. No adverse events related to study were reported.
Conclusion: Multi-strain probiotic along with dietary and lifestyle modifications were effective in the management of PCOS.
Trial Registration: CTRI: CTRI/2016/07/007086, dated 13 July 2016.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00394-022-02959-z | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!