Retrospective Study of the Relationship between Variable Benign Epilepsy of Childhood with Centrotemporal Spikes and the Changes of Zinc, MRS, VEEG, and IQ Test.

Benign epilepsy in childhood with centrotemporal spikes (VBECT) has been associated with electroencephalography (EEG), but the relationship of VBECT with zinc, magnetic resonance spectroscopy (MRS), and intelligence quotient (IQ) tests is unclear. The aim of this study was to investigate the association of VBECT with zinc, MRS, EEG, and IQ tests. In this retrospective study, we selected 58 children with variable benign epilepsy with centrotemporal spikes as the experimental group. A total of 120 children with typical benign childhood epilepsy with centrotemporal spikes were selected as the control group. The zinc, MRS, EEG, and IQ test results of 178 children were measured and analyzed. The results showed that the zinc, MRS, and IQ test results of the patients in the experimental group decreased significantly. The spinal slow wave results in the experimental group showed a significant upward trend. Linear correlation analysis of zinc with MRS, EEG, and IQ tests showed that 13 pairs of indicators were significantly negatively correlated. Our results suggest the importance of zinc, MRS, EEG, and IQ during VBECT.