Background: To the best of the authors' knowledge, this is the first case of microcystic/reticular schwannoma arising in the frontal bone.

Observations: An 18-year-old man presented to the authors' orthopedic clinic with a complaint of a progressively enlarging, painless mass in the frontal bone. It showed significant hyperintensity on T2-weighted imaging with progressive enhancement. Computed tomography combined with three-dimensional reconstruction showed expansive bone destruction with a soft tissue mass in the left side of the frontal bone, without calcification inside or a sclerotic margin around it. The mass was a microcystic/reticular schwannoma as confirmed by surgical pathology.

Lessons: The authors report a rare case of a microcystic/reticular schwannoma arising in the frontal bone, with relatively comprehensive imaging data that enabled them to learn more about this tumor.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245779PMC
http://dx.doi.org/10.3171/CASE21175DOI Listing

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  • * A study of 215 schwannomas revealed that 13.5% had the fusion, with the highest prevalence in peripheral somatic tissues, and a unique 'serpentine' palisading pattern was noted in most fusion-positive cases.
  • * The presence of this serpentine pattern correlated with the fusion status, suggesting it could be used as a predictive marker, along with tumor size, patient age, and location, while advanced RNA techniques confirmed the fusion's existence.
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Novel NONO::TFE3 fusion and ALK co-expression identified in a subset of cutaneous microcystic/reticular schwannoma.

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August 2023

Department of Pathology, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, 2119 E 93rd Street, L15, Cleveland, OH, 44195, USA.

Microcystic/reticular schwannoma (MRS) is a benign variant of schwannoma with a predilection for the gastrointestinal tract and skin. To date, genetic characterization of this tumor is limited. Prompted by the identification of TFE3::NONO fusion and ALK overexpression in an index case of MRS, a cohort of tumors was collected from institutional and consultation archives of two institutions.

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Background: To the best of the authors' knowledge, this is the first case of microcystic/reticular schwannoma arising in the frontal bone.

Observations: An 18-year-old man presented to the authors' orthopedic clinic with a complaint of a progressively enlarging, painless mass in the frontal bone. It showed significant hyperintensity on T2-weighted imaging with progressive enhancement.

View Article and Find Full Text PDF

Microcystic/reticular (MRV) schwannoma has been described since 2008, but remains a rarely encountered entity. MRV has a predilection for visceral locations and has variable histologic appareances. Given its rarity and anatomic variability, this entity could raise differential diagnostic issues with other tumours and malignancies.

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Primary tracheal microcystic reticular schwannoma - Case report of a rare neurogenic tumor treated by segmental tracheal resection.

Int J Surg Case Rep

February 2021

Klinik für Thoraxchirurgie, Stadtkrankenhaus Delmenhorst, Wildeshauser Str. 92, D-27753 Delmenhorst, Germany. Electronic address:

Introduction And Importance: Diagnosis and treatment of rare diseases are challenging because experience and evidence are limited. Primary tracheal tumors have a low prevalence but awareness of these is important to avoid misdiagnoses. We present a first case of a tracheal microcystic reticular schwannoma in which diagnosis and treatment recommendations were revised several times resulting in months of anxious uncertainty for the patient before complete resection and extensive histopathologic examination were performed.

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