A quantitative determination method for Al in immunobiological drugs using atomic absorption spectroscopy with electrothermal atomization was developed. Conditions for the preparation of aluminum hydroxide gel were selected [NaOH (5 M), heating in a boiling-water bath for 5 min followed by neutralization with conc. HNO]. The method was validated. The analytical range of Al was established in the interval 10 - 50 ig/L. The accuracy and in-laboratory precision were confirmed. The results allowed the proposed method to be considered an alternative for quantitative determination of Al in immunobiological drugs.
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| http://dx.doi.org/10.1007/s11094-022-02669-0 | DOI Listing |
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