AI Article Synopsis
- White matter hyperintensities (WMHs) are common in individuals with migraines, but their impact on migraine types and treatment effectiveness is not fully understood.
- The study analyzed 500 migraine patients to determine the relationship between WMHs and migraine phenotypes, as well as treatment responses based on headache pain intensity and frequency.
- Results showed that WMHs were more prevalent in older patients with longer migraine histories, and those who did not respond well to treatment had higher WMH presence; migraines with aura and symptoms like vomiting and dizziness were linked to increased WMH occurrence.
Article Abstract
Introduction: White matter hyperintensities (WMHs) are frequently found in migraineurs. However, their clinical significance and correlation to different migraine phenotypes and treatment responses are not well defined. The study aimed to examine the association of WMHs with migraine clinical patterns and treatment response.
Aim Of Work: We aimed to evaluate the association between WMHs and migraine phenotypes and explore the relationship of WMHs to treatment response.
Methods: Our cross-sectional study formed of 500 migraineurs who sought treatment in Kafr el-sheik university hospital and underwent (3 T) MRI to evaluate WMHs. Different migraine phenotypes were compared between patients with and without WMHs. According to reduced headache pain intensity and frequency, these patients were divided into treatment responder and non-responder groups.
Results: A total of 145 patients (29%) had WMHs. Patients with WMHs were significantly older, had a longer disease duration, and higher attack frequency. Patients who did not respond to acute and maintenance medications had a higher frequency of WMHs and high WMHs Scheltens score. Migraine with Aura and the presence of vomiting and dizziness were predictors for the development of WMHs.
Conclusion: WMHs are more common in migraine with aura. It is more frequent in migraine associated with vomiting and dizziness. WMHs increased with advancing age and more severe disease burden. Poorer response to acute and prophylactic medications was found in patients with WMHs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505107 | PMC |
| http://dx.doi.org/10.1007/s13760-022-02015-x | DOI Listing |
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