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Aphasia Associated With Acute on Chronic Kidney Failure in an Adolescent.
Cureus
November 2023
Department of Pediatrics, Duke University School of Medicine, Durham, USA.
Acute and chronic kidney disease (CKD) have known neurological associations resulting from uremia, electrolyte disturbances, comorbidities such as hypertension, or other toxin accumulation. Reversible focal neurological deficits are relatively uncommon and poorly understood sequelae of kidney disease. Herein, we describe an unusual case of an adolescent male who developed acute aphasia during his initial presentation for acute kidney injury (AKI) superimposed on progressive CKD stage 5 associated with uremia and multiple electrolyte derangements.
View Article and Find Full Text PDFIntravenous Thrombolysis Improved Aphemia and Confirmed the Dominant Precentral Gyrus as the Responsible Lesion.
Cureus
October 2023
Neurological Surgery, Saiseikai Toyama Hospital, Toyama, JPN.
Aphemia is now considered an impairment of speech production. We present a case of an 89-year-old right-handed woman who received intravenous thrombolysis with a recombinant tissue plasminogen activator for the ischemic symptom "loss of speech" and recovered with an ischemic lesion of the left precentral gyrus. The patient had untreated atrial fibrillation.
View Article and Find Full Text PDFWe report a case of Broca's aphasia in a left-handed patient with a right brain infarction. The patient's speech is consistent with a particular type of aphemia, that is, without vocalization except for a few phonemes or words. The patient presented with aphonia in an early stage.
View Article and Find Full Text PDFALS due to a novel TBK1 mutation in Brazil.
Amyotroph Lateral Scler Frontotemporal Degener
November 2022
Departamento de Neurociências, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.
TANK-binding kinase 1 (TBK1) gene mutations cause ALS and frontotemporal dementia (FTD). We report a novel TBK1 mutation in a Brazilian patient with ALS. Symptoms started at age 44 (lower-limb onset).
View Article and Find Full Text PDFA case of aphemia following non-dominant sub-insular stroke: unveiling the Foix-Chavany-Marie phenomenon.
Neurocase
June 2021
Neurology and Radiology, Associate Dean for Continuing Medical Education, Washington University School of Medicine, St. Louis, MO, USA.
Aphemia refers to the clinical syndrome of inability to orally produce speech with intact comprehension and written expression. Aphemia has been primarily reported in dominant frontal lobe strokes resulting in apraxia of speech (AoS), and in Foix-Chavany-Marie (FCM) syndrome where bilateral opercular or sub-opercular lesions result in anarthria due to deafferentation of brainstem nuclei supplying the oro-facio-lingual and pharyngeal musculature. Aphemia is not reported in non-dominant sub-insular strokes.
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