Our study aimed to develop a self-microemulsifying drug delivery system for the poorly aqueous-soluble drug Coenzyme Q, to improve the dissolution and the oral bioavailability. Excipients were selected based on their Coenzyme Q solubility, and their concentrations were set for the optimization of the microemulsion by using a D-optimal mixture design to achieve a minimum droplet size and a maximum solubility of Coenzyme Q within 15 min. The optimized formulation was composed of an oil (omega-3; 38.55%), a co-surfactant (Lauroglycol® 90; 31.42%), and a surfactant (Gelucire 44/14; 30%) and exhibited a mean droplet size of 237.6 ± 5.8 nm and a drug solubilization (at 15 min) of 16 ± 2.48%. The drug dissolution of the optimized formulation conducted over 8 h in phosphate buffer medium (pH 6.8) was significantly higher when compared to that of the Coenzyme Q suspension. A pharmacokinetic study in rats revealed a 4.5-fold and a 4.1-fold increase in the area under curve and the peak plasma concentration values generated by the optimized formulation respectively, as compared to the Coenzyme Q suspension. A Coenzyme Q brain distribution study revealed a higher Coenzyme Q distribution in the brains of rats treated with the optimized formulation than the Coenzyme Q suspension. Coenzyme Q-loaded self microemulsifying drug delivery system was successfully formulated and optimized by a response surface methodology based on a D-optimal mixture design and could be used as a delivery vehicle for the enhancement of the oral bioavailability and brain distribution of poorly soluble drugs such as Coenzyme Q.
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http://dx.doi.org/10.1080/10717544.2022.2100515 | DOI Listing |
PLoS One
January 2025
School of Pharmaceutical Economics and Management, Anhui University of Traditional Chinese Medicine, Hefei, Anhui, China.
The evolution of the spatiotemporal relationship between urban economic growth and health resources within the Yangtze River Delta urban agglomeration provides an important context for understanding the regional development dynamics in China. Previous studies focused on equity in health-resource allocation and service efficiency, often overlooking the allometric growth relationships between health resources and economic variables. This study employs an allometric growth model to elucidate the changing interactions between the number of medical beds, doctors, and urban economic indicators in the Yangtze River Delta region from 2009 to 2022.
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January 2025
Radiology Department, Liverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool, UK.
Optimal management of adult congenital heart disease (ACHD) requires a multidisciplinary team (MDT) approach, fostering a collaborative culture over an individualistic approach. Within this framework, subspecialty-trained radiologists provide crucial imaging expertise, supporting cardiologists, surgeons, and interventional cardiologists in diagnoses, treatment planning, and follow-up evaluations. Advanced imaging tools and a nuanced understanding of surgical and interventional procedures enable radiologists to provide valuable insights to clinicians.
View Article and Find Full Text PDFToxics
January 2025
Department of Chemical Engineering, Faculty of Sciences, University of Granada, Campus Fuente Nueva s/n, 18071 Granada, Spain.
Surfactants play a crucial role in various industrial applications, including detergents and personal care products. However, their widespread use raises concerns due to their potential environmental impact and health risks, particularly in aquatic ecosystems, where they can disrupt the balance of marine life and accumulate in water sources, posing challenges to sustainable development. This study investigates the environmental and health implications of anionic and nonionic surfactants, focusing on their toxicity, biodegradation, and skin irritation potential profiles, especially when combined with silica nanoparticles.
View Article and Find Full Text PDFVet Sci
January 2025
Centre for Interdisciplinary Research in Animal Health (CIISA), Faculty of Veterinary Medicine, University of Lisbon, Av. da Universidade Técnica de Lisboa, 1300-477 Lisbon, Portugal.
The use of recycled manure solids (RMS) as cow bedding in dairy farms poses concerns due to its potential to harbor pathogenic and antimicrobial-resistant bacteria. This study evaluated the impact of RMS supplementation with biochar at three concentrations (2.5%, 5%, and 10%) on bacterial counts and on the antimicrobial resistance and virulence profiles of and isolates.
View Article and Find Full Text PDFNanomaterials (Basel)
January 2025
Department of Inorganic and Organic Chemistry, University Jaume I, Av. Vicent Sos Baynat s/n, 12071 Castellón de la Plana, Spain.
In this work, a series of BaMnCuO samples (x: 1, 0.9, 0.8, and 0.
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