AI Article Synopsis
- Bone graft materials are used to fill bone defects and support implant placement, but current options often fail to be fully replaced by new bone within 3 to 6 months.
- A new material called Bonewool, made from biodegradable PLGA fibers with ß-TCP nanoparticles, was tested against Bio-Oss, a common bovine hydroxyapatite graft.
- The study found that Bonewool showed a more progressive degradation behavior, suggesting it could be fully resorbed, making it a promising alternative for bone augmentation.
Article Abstract
Bone graft materials are applied in patients to augment bone defects and enable the insertion of an implant in its ideal position. However, the currently available augmentation materials do not meet the requirements of being completely resorbed and replaced by new bone within 3 to 6 months. A novel electrospun cotton-wool like material (Bonewool, Zurich Biomaterials LLC, Zurich, Switzerland) consisting of biodegradable poly(lactic-co-glycolic) acid (PLGA) fibers with incorporated amorphous ß-tricalcium phosphate (ß-TCP) nanoparticles has been compared to a frequently used bovine derived hydroxyapatite (Bio-Oss, Geistlich Pharma, Wolhusen, Switzerland) in vitro. The material composition was determined and the degradation behavior (calcium release and pH in different solutions) as well as bioactivity has been measured. Degradation behavior of PLGA/ß-TCP was generally more progressive than for Bio-Oss, indicating that this material is potentially completely resorbable. Graphical abstract.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293850 | PMC |
| http://dx.doi.org/10.1007/s10856-022-06682-3 | DOI Listing |
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