AI Article Synopsis
- Novel human astroviruses (HAstVs) are being linked to severe encephalitis in patients with weakened immune systems, and there are currently no effective treatments available.
- Two cases from a medical facility were identified where HAstV-VA1 was found in the cerebrospinal fluid using advanced metagenomic next-generation sequencing methods.
- These findings occurred after standard diagnostic evaluations did not determine any cause for the patients' encephalitis.
Article Abstract
Novel human astroviruses (HAstVs) have recently been implicated as rare causes of fatal encephalitis in immunocompromised patients, for which there is no proven treatment. We report 2 cases from our institution in which HAstV-VA1 was detected in the cerebrospinal fluid by metagenomic next-generation sequencing after the initial evaluation revealed no etiology.
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| http://dx.doi.org/10.1093/jpids/piac045 | DOI Listing |
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