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| http://dx.doi.org/10.4103/sjg.sjg_261_22 | DOI Listing |
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Intragastric botulinum toxin injection for weight loss: current trends, shortcomings and future perspective.
Clin Endosc
November 2024
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
The administration of botulinum toxin A (BTA) into the gastric wall has emerged as a novel endoscopic bariatric procedure. Although over 20 years have elapsed since the initial human trial of intragastric BTA injection, considerable debate remains surrounding the safety, efficacy, and procedural instructions of this approach. The current literature exhibits discrepancies in the methodologies employed across studies, including differences in the dosage of BTA administered, injection site, number and depth of injections, post-procedural dietary modifications, and follow-up duration.
View Article and Find Full Text PDFIntragastric botulinum toxin injection: a promising alternative for obesity treatment?
Arch Med Sci
October 2024
Department of General Surgery, Bülent Ecevit University School of Medicine, Zonguldak, Turkey.
Introduction: Over the past 50 years, the rise in obesity has prompted a search for new treatments. Intragastric injections of botulinum toxin A (BT-A), a safer alternative to surgery, show promise in reducing weight and caloric intake by inducing early satiety. This study examines their efficacy for weight loss.
View Article and Find Full Text PDFIatrogenic botulism after intragastric botulinum neurotoxin injections - a major outbreak.
Neurol Res Pract
October 2024
Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.
Article Synopsis
- Intragastric botulinum neurotoxin injections (IBNI) are being used as a weight-loss treatment, but an outbreak of severe iatrogenic botulism occurred in early 2023 in Europe after patients received this treatment in Turkey.
- A retrospective analysis was conducted on ten patients in Austria and Germany who experienced severe symptoms like double vision, swallowing difficulties, and paralysis after IBNI.
- Despite the severity of their conditions, all patients were hospitalized, many in intensive care, and ultimately recovered without lasting health issues, underscoring the need for awareness and risk mitigation in medical procedures involving botulinum neurotoxins.
["Cosmetic" iatrogenic botulism : description of 2 cases in Switzerland].
Rev Med Suisse
October 2024
Service de médecine interne, Centre hospitalier de Bienne, 2502 Bienne.
Article Synopsis
- Botulism is a serious condition caused by a toxic protein from the bacteria Clostridium botulinum, leading to paralysis by blocking neurotransmitter release.
- The poisoning can occur from eating contaminated food, inhaling the toxin, or through skin contact.
- In 2023, there was an outbreak of iatrogenic botulism in Europe linked to intragastric injections, and this text discusses this phenomenon along with two specific cases from Switzerland.
Intragastric botulinum toxin injection directly regulates ghrelin expression via reactive oxygen species and NF-κB signaling.
Life Sci
November 2024
Department of Internal Medicine, School of Medicine, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan; Tong-Yuan Diabetes Center, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. Electronic address:
Aims: One effective clinical strategy to combat obesity is intragastric botulinum toxin (BTX) injection, which increases gastric emptying time and regulates appetite. However, it remains unknown if and how BTX affects ghrelin levels.
Materials And Methods: An obese animal model was established by feeding male mice with high-fat diet (HFD).
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