AI Article Synopsis
- The study assessed the prevalence and trends of Helicobacter pylori (H. pylori) infection and its link to gastric cancer in Taiwan between 2019-2020.
- Involved 1,494 participants, showing H. pylori infection at 26.6% overall, with a significant drop in prevalence from 63.8% (1990-2000) to 28.2% (2016-2020).
- There's a corresponding decline in age-standardized incidence and mortality rates of gastric cancer, suggesting that decreasing H. pylori rates may lower cancer risks.
Article Abstract
Background: We aimed to assess the latest prevalence and secular trend of Helicobacter pylori infection and its association with the incidence and mortality of gastric cancer in Taiwan.
Materials And Methods: Adults naive to H. pylori eradication received C-urea breath test ( C-UBT), H. pylori stool antigen test, and serology test during 2019-2020 in this prospective screening program. Children and adolescent aged between 7 and 19 years received C-UBT for H. pylori screening. We also conducted a systematic review and meta-analysis to assess the secular trend of prevalence of H. pylori from 1990 to 2020 in Taiwan. The secular trends of age-standardized incidence and mortality of gastric cancer were obtained from the Taiwan Cancer Registry.
Results: A total of 1494 participants were enrolled, including 294 children or adolescents and 1200 adults. The overall prevalence of active H. pylori infection by C-UBT was 26.6% (397/1494), which was 30.8% in adults and 9.5% in adolescents/children. The age-standardized prevalence of active H. pylori infection was 32.3% in adults after adjustment of the population structure in Taiwan. Of the 29 studies including 38,597 subjects eligible for the meta-analysis, the pooled prevalence of H. pylori infection decreased from 63.8% (95% CI: 55.9%-71%) in 1990-2000 to 28.2% (95% CI:21.8%-35.6%) in 2016-2020. The age-standardized incidence and mortality of gastric cancer have also declined from 15.2 to 10.75 per 100,000, respectively, in 1999 to 9.29 and 5.4 per 100,000, respectively, in 2019.
Conclusions: The prevalence of H. pylori infection has declined in Taiwan, which correlates with the declining trends of age-standardized incidence and mortality of gastric cancer in Taiwan.
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| http://dx.doi.org/10.1111/hel.12914 | DOI Listing |
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