A ring expansion of tetramic acids (pyrrolidine-2,4-diones) to -oxy-2,5-diketopiperazines (DKPs) is described. This method allows for the facile and late-stage construction of the hydroxamic acid moiety and can thereby serve as a general method for accessing -oxy-2,5-DKP natural products.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281442 | PMC |
| http://dx.doi.org/10.1016/j.tetlet.2022.153851 | DOI Listing |
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