Association Between Left Atrial Appendage Morphology and Function and the Risk of Ischaemic Stroke in Patients with Atrial Fibrillation.

Arrhythm Electrophysiol Rev

Division of Clinical Electrophysiology, Department of Cardiology Centre of Postgraduate Medical Education, Grochowski Hospital, Warsaw, Poland.

Published: April 2022

AF is the most common cardiac arrhythmia and has been identified as an independent risk factor for stroke. The European Society of Cardiology guidelines recommend a thromboembolic event risk assessment based on the CHADS-VASc score. However, stroke also occurs in some patients with a low CHADS-VASc score. Therefore, it is necessary to find new factors to improve thromboembolic risk stratification in AF patients. Over 90% of embolic strokes are caused by thrombi originating from the left atrial appendage (LAA). Thus, certain anatomical or functional parameters of the LAA could potentially be used to predict cardioembolic stroke. Studies have suggested that some of these factors, such as LAA morphology, number of LAA lobes, LAA dimensions, LAA volume, distance from the LAA ostium to the first bend of LAA, LAA orifice diameter, extent of LAA trabeculations, LAA takeoff, LAA flow velocity and LAA strain rate, are independently associated with a higher risk of stroke in a population of patients with AF and improve the performance of the CHADS-VASc score. However, the results are conflicting and, so far, no new parameter has been added to the CHADS-VASc score.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272406PMC
http://dx.doi.org/10.15420/aer.2022.08DOI Listing

Publication Analysis

Top Keywords

chads-vasc score
16
laa
13
left atrial
8
atrial appendage
8
risk
5
stroke
5
association left
4
appendage morphology
4
morphology function
4
function risk
4

Similar Publications

This study examines the correlation between time-in-therapeutic range (TTR) and anticoagulation-related adverse events (AEs) in patients with atrial fibrillation (Afib) in a pharmacist-managed ambulatory care clinic. A single-center, retrospective cohort study was conducted at a community hospital-based outpatient anticoagulation clinic to investigate the predictive value of suboptimal TTR percentages for hemorrhagic or thromboembolic events in Afib patients. Eligible participants were aged 18 years or older, diagnosed with Afib, and receiving warfarin therapy as current or past enrollees in the anticoagulation management program.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to determine the effectiveness and safety of low-dose direct oral anticoagulation (DOAC) compared to dual antiplatelet therapy (DAPT) in patients who underwent left atrial appendage occlusion (LAAO) for three months post-procedure.
  • Conducted across three European sites, the ADALA trial faced challenges with participant recruitment due to the COVID-19 pandemic and was halted prematurely, involving only 90 patients.
  • The main outcomes assessed included the rates of major bleeding and thromboembolic events, with the study analyzing patients who had a history of bleeding and various health profiles.
View Article and Find Full Text PDF

: The necessity of using central venous catheters (CVCs) in hemodialysis, coupled with their associated complications, remains a critical concern in nephrology. This study aims to compare the short-term prognosis of tunneled (T-CVC) and non-tunneled (NT-CVC) CVCs in acute hemodialysis patients, specifically focusing on infection rates, malpositioning, and lumen thrombosis within the first three weeks post-insertion. : A retrospective analysis was conducted on 176 CVCs placed between January and December 2023 at the Policlinico di Modena and the Ospedale Civile di Baggiovara.

View Article and Find Full Text PDF

Contrast-free left atrial appendage occlusion in patients using the LAMBRE™ device.

Int J Cardiol

June 2024

Herzzentrum Bonn, University Hospital Bonn, Germany; RheinAhrCardio, Praxis für Kardiologie, Bad-Neuenahr Ahrweiler, Germany. Electronic address:

Background: Advances in imaging have led to procedural optimization of left atrial appendage closure (LAAC). Contrast-free approaches, guided merely by echocardiography, have been established, however data on this topic remains scarce. In this analysis, we assessed contrast-free procedural results with the LAMBRE LAAC device.

View Article and Find Full Text PDF

ECG predictors of AF: A systematic review (predicting AF in ischaemic stroke-PrAFIS).

Clin Neurol Neurosurg

February 2024

Department of Medicine, Grampians Health Ballarat, Australia; School of Medicine, Deakin University, Australia.

Article Synopsis
  • About 25% of patients with embolic stroke have an unknown cause, but atrial fibrillation (AF) is a common mechanism, especially in older individuals.
  • A systematic review of studies was conducted to identify ECG patterns that can predict AF in patients already in sinus rhythm.
  • The findings revealed multiple ECG abnormalities linked to increased AF risk, and clinical factors like age and chronic diseases can enhance predictive accuracy, potentially aiding in better patient management and treatment.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!