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Mutational spectrum and prognosis in Chinese patients with prefibrotic primary myelofibrosis. | LitMetric

AI Article Synopsis

Article Abstract

Prefibrotic primary myelofibrosis (Pre-PMF) has been classified as a separate entity of myeloproliferative neoplasms (MPNs). Pre-PMF is clinically heterogeneous but a specific prognostic model is lacking. Gene mutations have emerged as useful tools for stratification of myelofibrosis patients. However, there have been limited studies comprehensively investigating the mutational spectrum and its clinicopathological significance in pre-PMF subjects. In this study, we addressed these issues by profiling the mutation status of 141 genes in 172 Chinese MPN patients including 72 pre-PMF cases. Our findings corroborated the clinical/molecular distinctiveness of pre-PMF and suggested a refined risk classification strategy for this entity.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176118PMC
http://dx.doi.org/10.1002/jha2.361DOI Listing

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